Cleavage of growth hormone by rabbit liver plasmalemma enhances binding.

Schepper, Jeanette M.; Hughes, E F; Postel-Vinay, Marie-Catherine; Hughes, James P.

doi:10.1016/s0021-9258(18)90636-8

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1988

2000

Publication Types

Select...

Book3

Other2

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 27 publications

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Hormones, Human Growth Hormone

Becker¹,

MacKellar²,

Riggin³

et al. 2000

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

Human growth hormone (hGH), a protein hormone produced and secreted by the somatotropic cells of the anterior pituitary, plays a key role in somatic growth through its effects on the metabolism of proteins, carbohydrates, and lipids. The biological properties of hGH are diverse and complex, with the molecule exhibiting anabolic activity, insulin‐like and diabetogenic activities, and lactogenic activity, as well as producing effects on water and salt retention. First isolated from the pituitary gland, hGH is produced using recombinant DNA technology and has been approved for use as a human pharmaceutical in the treatment of growth failure owing to hGH deficiency and in the treatment of Turner's syndrome in Europe and Japan. In addition, hGH is being investigated for use in treating burns, various wounds, osteoporosis, cachexia, and other conditions. Human growth hormone is one of the largest selling therapeutic proteins produced by recombinant DNA technology.

show abstract