Cleavage of the Pt–S bond of thiolated terpyridine–platinum(II) complexes by copper(II) and zinc(II) ions in phosphate buffer

Abstract

Cu 2 or Zn 2+ phosphate buffer (pH 7-8), room temp. Received inCambridge, UK, 12th November 1997; 7/08152I Fig. 2 Comparison of the reactivity in the cleavage of the Pt-S bond by Zn 2+ , Cu 2+ and Ni 2+ ions. These data were collected at a fixed absorption wavelength of 342 nm at intervals of 50 s per cycle at a concentration of [Pt(terpy)(BAT)] 4+ (40 mm) and metal ion (40-42 mm) in 10 mm phosphate buffer (pH 8.0) at room temp. (5) Zn 2+ , ( ~) Cu 2+ , (-) Ni 2+ .

Why Does Cisplatin Reach Guanine-N7 with Competing S-Donor Ligands Available in the Cell?

“…But in such studies attention should also be given to physiological conditions, as other metals in the cell are likely to play a (co)role in the disruption of Pt−S bonds. Addition of transition metals such as Zn 2+ or Cu 2+ can cleave even the Pt−S bond in thiolated terpyridine−platinum complexes at neutral pH, as was recently reported.…”

The Anionic Polymerization of a tert-Butyl-Carboxylate-Activated Aziridine

“…BocAz has been reported previously [48][49][50], but its polymerization has not been explored. We synthesized BocAz from ethanolamine by first reacting ethanolamine with di-tert-butyl dicarbonate to form tert-butyl (2-hydroxyethyl)carbamate (Scheme 2A).…”

“…An important advantage of Boc compared to sulfonyl groups is that Boc can undergo deprotection using relatively mild acidic conditions. There are examples of the nucleophilic ring-opening of BocAz in the synthesis of small molecules, although its polymerization chemistry has not been explored [48][49][50].…”