Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients

Komine, Ken Ichi; Kuroishi, Toshinobu; Ozawa, Akiko; Komine, Yumiko; Minami, T.; Shimauchi, Hidetoshi; Sugawara, Shunji

doi:10.1016/j.molimm.2006.09.003

Cited by 33 publications

(36 citation statements)

References 55 publications

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“…Although the functional role of cathepsin G is well characterized in a variety of pathologic conditions including rheumatoid arthritis (20), coronary artery disease (21), periodontitis (22), and ischemic reperfusion injury (23), this is the first report of its involvement in bone metastasis. Interestingly, however, the source of cathepsin G in rheumatoid arthritis is macrophages (20).…”

Section: Discussionmentioning

confidence: 97%

Cathepsin G Enhances Mammary Tumor–Induced Osteolysis by Generating Soluble Receptor Activator of Nuclear Factor-κB Ligand

et al. 2008

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Breast cancer commonly causes osteolytic metastases in bone, a process that is dependent on tumor-stromal interaction. Proteases play an important role in modulating tumorstromal interactions in a manner that favors tumor establishment and progression. Whereas several studies have examined the role of proteases in modulating the bone microenvironment, little is currently known about their role in tumor-bone interaction during osteolytic metastasis. In cancer-induced osteolytic lesions, cleavage of receptor activator of nuclear factor-KB ligand (RANKL) to a soluble version (sRANKL) is critical for widespread osteoclast activation. Using a mouse model that mimics osteolytic changes associated with breast cancer-induced bone metastases, we identified cathepsin G, cathepsin K, matrix metalloproteinase (MMP)-9, and MMP13 to be proteases that are up-regulated at the tumor-bone interface using comparative cDNA microarray analysis and quantitative reverse transcription-PCR. Moreover, we showed that cathepsin G is capable of shedding the extracellular domain of RANKL, generating active sRANKL that is capable of inducing differentiation and activation of osteoclast precursors. The major source of cathepsin G at the tumor-bone interface seems to be osteoclasts that up-regulate production of cathepsin G via interaction with tumor cells. Furthermore, we showed that in vitro osteoclastogenesis is reduced by inhibition of cathepsin G in a coculture model and that in vivo inhibition of cathepsin G reduces mammary tumor-induced osteolysis. Together, our data indicate that cathepsin G activity at the tumor-bone interface plays an important role in mammary tumor-induced osteolysis and suggest that cathepsin G is a potentially novel therapeutic target in the treatment of breast cancer bone metastasis. [Cancer Res 2008;68(14):5803-11]

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Section: Discussionmentioning

confidence: 97%

Cathepsin G Enhances Mammary Tumor–Induced Osteolysis by Generating Soluble Receptor Activator of Nuclear Factor-κB Ligand

et al. 2008

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“…Also noteworthy is the study of Shimauchi et al [31], which showed that probiotics significantly decreased the salivary lactoferrin levels in smokers with chronic periodontitis. Lactoferrin is a member of the transferrin family of iron-binding proteins and its high salivary concentration is associated with periodontal inflammation [56].…”

Section: Discussionmentioning

confidence: 99%

The role of probiotic bacteria in managing periodontal disease: a systematic review

Matsubara

Bandara

Ishikawa

et al. 2016

Expert Review of Anti-infective Therapy

130

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“…Occurrence of inflammatory LF peptides in saliva of chronic periodontitis patients Komine et al (2007) Bovine Reduction of P. gingivalis and P. intermedia in subgingival plaque of chronic periodontitis patients Kondo et al (2008) Human and bovine…”

Section: Humanmentioning

confidence: 99%

“…On the other hand, hLF is degraded strongly by P. gingivalis and weakly by P. intermedia (Alugupalli and Kalfas 1996;de Lillo et al 1996). A recent study showed that hLF peptides with no anti-Escherichia coli activity and reduced iron-chelating capacity are present in the parotid saliva of chronic periodontitis patients (Komine et al 2007). Although they suggested that the peptides exhibit inflammatory activity and are produced by proteolysis with proteinase 3 co-localizing in the parotid saliva, the protease seems to be of host, but not bacterial.…”

Section: Humanmentioning

confidence: 99%

Periodontitis, periodontopathic bacteria and lactoferrin

et al. 2010

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Lactoferrin (LF) is a component of saliva and is suspected to be a defense factor against oral pathogens including Streptococcus mutans and Candida albicans. Periodontitis is a very common oral disease caused by periodontopathic bacteria. Antimicrobial activities and other biological effects of LF against representative periodontopathic bacteria, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia, have been widely studied. Association of polymorphisms in LF with incidence of aggressive periodontitis and the role of LF in the gingival crevicular fluid as a marker of periodontitis severity have also been reported. Periodontopathic bacteria reside as a biofilm in supragingival and subgingival plaque. Our recent study indicated that LF exhibits antibacterial activity against planktonic forms of P. gingivalis and P. intermedia at higher concentrations, and furthermore, LF effectively inhibits biofilm formation and reduces the established biofilm of these bacteria at physiological concentrations. A small-scale clinical study indicated that oral administration of bovine LF reduces P. gingivalis and P. intermedia in the subgingival plaque of chronic periodontitis patients. LF seems to be a biofilm inhibitor of periodontopathic bacteria in vitro and in vivo.

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Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients

Cited by 33 publications

References 55 publications

Cathepsin G Enhances Mammary Tumor–Induced Osteolysis by Generating Soluble Receptor Activator of Nuclear Factor-κB Ligand

Cathepsin G Enhances Mammary Tumor–Induced Osteolysis by Generating Soluble Receptor Activator of Nuclear Factor-κB Ligand

The role of probiotic bacteria in managing periodontal disease: a systematic review

Periodontitis, periodontopathic bacteria and lactoferrin

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