Cleft LIP and palate in babies with microcephaly by zika virus: would there be an etiopathogenic relationship?

Guimarães, G. M. M. F.; Oliveira, Isadora Abreu; Sousa, Pablo; Doriqui, Maria Juliana R.; Fiamoncini, Eduardo Stedile; Júnior, Osny Ferreira; Consolaro, Alberto

doi:10.1016/j.ijom.2019.03.060

Cited by 2 publications

(4 citation statements)

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“…The results are presented in Supplemental Table 1 (Supplemental Digital Content 1, http://links.lww.com/SCS/E882). [25][26][27][28][29] The validator RBV, a member of the genus Rubivirus, scored 14 and was defined as the threshold for the high potential to cause CL/P. The mean threshold was defined as ZIKV with a score of 10, and the HHV-1 validator with a score of 7 and below was considered the threshold for the low potential to cause CL/P.…”

Section: Resultsmentioning

confidence: 99%

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Investigation of Flaviviruses Emerging in Brazil as Etiology Factor in Nonsyndromic Orofacial Cleft

Silva

Messias

Soares

2023

Journal of Craniofacial Surgery

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Brazil has one of the largest forest areas on the planet and the potential for the emergence of new diseases. In turn, orofacial clefts, especially cleft lip and or palate (CL/P), are characterized as congenital malformations and may be associated with genetic and environmental factors. The present study aimed to investigate in silico the flavivirus's potential to emerge in Brazil as an etiology of CL/P. A scoring method was created based on literature and nucleotide similarity analysis. An integrative analysis of the literature was performed to answer the questions through the databases PubMed/MEDLINE, SciELO, LILACS, and Google Scholar to have a more significant number of results. The software Basic Local Alignment Search Tool-BLAST 2.12.0, through the Genomic + Transcript Databases (Human Genomic plus Transcript Human G +T), was selected to find similarities with human sequences associated with CL/P. The viral sequences used were obtained from the National Center for Biotechnology Information Virus -NCBI Virus, in which only complete and referential genomes were selected. The flavivirus that emerged in Brazil and presented a high potential to cause CL/P was the Iguape virus strain (species Aroa virus), followed by the Cacipacore virus and the Rocio virus strain (species Ilheus virus) with medium potential to cause CL/P. In conclusion, we suggest among the virus evaluated that the Iguape virus presented a high potential of causing CL/P. As prevention, the control of arthropods and the hospital diffusion on viral dynamics, mainly in the CL/P context and other congenital malformations, are indicated.

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Section: Resultsmentioning

confidence: 99%

“…The results are presented in Supplemental Table 1 (Supplemental Digital Content 1, http://links.lww.com/SCS/E882). 25–29…”

Section: Resultsmentioning

confidence: 99%

Investigation of Flaviviruses Emerging in Brazil as Etiology Factor in Nonsyndromic Orofacial Cleft

Silva

Messias

Soares

2023

Journal of Craniofacial Surgery

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“…While bats are known to host a diverse number of viruses of livestock and human health significance, little investigation has been conducted into viral pathogens that may have a conservation impact on endangered bat species. In utero virus infection with individual virus species in virus families as diverse as Herpesviridae , Flaviviridae , Paramyxoviridae , Picornaviridae , Bunyaviridae , and Retroviridae [ 22 , 23 , 24 , 25 , 26 , 52 , 53 ], have been shown to be associated with congenital birth deformities in both animal species and humans. Additionally, the interaction between the host genome and viral infection is an important relationship to consider when forming etiological hypotheses for a syndrome that may involve a complex genetic–environment interaction.…”

Section: Discussionmentioning

confidence: 99%

“…As bats are known to host many and varied viral infections [ 21 ], it is important to consider in utero viral infection as a putative aetiology of cleft palate in bat species. There is commonality in virus families that have been reported in the aetiology of cleft palate in both human and animal species inclusive of the Herpesviridae and Flaviviridae families [ 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Cleft Palate Syndrome in the Endangered Spectacled Flying Fox (Pteropus conspicillatus): Implications for Conservation and Comparative Research

McMichael

Mclean²,

Taylor

et al. 2023

Veterinary Sciences

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Cleft palate syndrome, first observed in the spectacled flying fox population in 1998, has produced sporadic neonatal mortality events over the past two decades, with an estimated incidence of up to 1/1000 births per year. This study presents a rudimentary characterisation of the syndrome, presenting gross pathology of syndromic signs upon visual inspection, a histological examination of palate malformations, and syndrome incidence data representing the past two decades. The syndrome presents with a range of signs, primarily congenital palate malformations ranging from a pinhole cleft to a complete hard and soft palate deficit, resulting in the death or abandonment of neonates shortly after birth. The congenital palate malformations are often associated with claw deformities, wiry facial hair, and in some instances, muscle weakness and neurological signs. The natural occurrence of the lethal congenital orofacial birth defects in the spectacled flying fox presents a unique opportunity for the investigation of putative aetiologies, drawing parallels between bat and other mammalian cleft palate risk factors. Further syndrome investigation has the potential to deliver both biodiversity conservation and comparative veterinary and biomedical outcomes.

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Cleft LIP and palate in babies with microcephaly by zika virus: would there be an etiopathogenic relationship?

Cited by 2 publications

References 0 publications

Investigation of Flaviviruses Emerging in Brazil as Etiology Factor in Nonsyndromic Orofacial Cleft

Investigation of Flaviviruses Emerging in Brazil as Etiology Factor in Nonsyndromic Orofacial Cleft

Cleft Palate Syndrome in the Endangered Spectacled Flying Fox (Pteropus conspicillatus): Implications for Conservation and Comparative Research

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