Cleft lip, nose, and palate: the nasal septum as the pacemaker for midfacial growth

Hall, Brian K.; Precious, David S.

doi:10.1016/j.oooo.2012.05.005

Cited by 60 publications

(88 citation statements)

References 24 publications

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“…Previously it was thought that primary correction of nasal deformity in cleft lip patients would cause developmental impairment of the nose and to a certain extent this hypothesis still draws evidence (Hall and Precious, 2012). There is a growing acceptance that simultaneous correction of the cleft lip nasal deformity has no adverse effect on nasal growth.…”

Section: Discussionmentioning

confidence: 99%

Unilateral cleft lip/nose repair using an equal bows /straight line advancement technique – A preliminary report and postoperative symmetry-based anthropometry

Hakim

Aschoff

Jacobsen

et al. 2014

Journal of Cranio-Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Unilateral cleft lip/nose repair using an equal bows /straight line advancement technique – A preliminary report and postoperative symmetry-based anthropometry

Hakim

Aschoff

Jacobsen

et al. 2014

Journal of Cranio-Maxillofacial Surgery

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“…B.K. Hall, et al (2013) noted the importance of the nasal septum as a pacemaker for midfacial growth, and its effect on skeletal and soft tissues [4].…”

Section: Peculiarities Of the Upper Lip Morphogenesis And Its Relatiomentioning

confidence: 99%

“…When the coordinated development of these processes and the tongue is damaged, a cleft between the processes may develop. The exact time of palatine closure and critical periods of its development are still insufficiently studied [4,5,19].…”

Section: Peculiarities Of the Upper Lip Morphogenesis And Its Relatiomentioning

confidence: 99%

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Peculiarities of the Upper Lip Morphogenesis and Its Relation to Facial Development

et al. 2017

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An appreciation of the fundamental principles associated with the development of the craniofacial structures is essential for attaining competency within the fields of facial surgery, dentistry and pediatrics. The objective of this literature review was to highlight the main stages and precise time ranges of human upper lip development, as well as to elucidate the fundamental mechanisms of normal morphogenesis and possible congenital malformations. The structures of the head and neck arise from the lateral portion of the neural tube, which forms five pairs of branchial arches. Recent studies have identified various molecular pathways (including Bmp, Fgf and Shh signaling) and genetic mechanisms in human face development. Primordial structures of the upper lip begin to appear early within the 6th week of ontogenesis; their development involves a number of highly coordinated, genetically programmed ontogenetic mechanisms that include growth and expansion of the facial prominences, programmed cell death, active fusion and breakdown of the epithelial seam between the initially freely maxillary, medial nasal, and lateral nasal processes. Defects of epithelial and mesenchymal fusion during upper lip formation result in orofacial cleft. Further research should be directed to studying normal ontogenesis at the molecular and topographical levels with the determination of critical periods, time ranges and developmental stages that are sensitive to teratogens.

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“…During development and growth of the nasal septum, or in the process of ossification, imbalanced growth between the nasal bones or between the bones and cartilage may lead to nasal septum malformation and/or deviation, leading to formation of an apophysis at the nasal crest and/or junction (4). This process represents the elastic strain model of NSD.…”

Section: Introductionmentioning

confidence: 99%

Measurement of deformation rate in nasal septum deviation by three-dimensional computer tomography reconstruction and its application in nasal septoplasty endoscopic surgery

Yang

Zhao

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Nasal septum deviation (NSD) typically occurs following otorhinolaryngologic surgery. However, there is a lack of biomechanical parameters able to accurately evaluate the severity of NSD. The present study aimed to determine whether the deformation rate (DR) is associated with visual analogue scale (VAS) and nasal airway resistance (NAR), and to evaluate the application of DR measurements in nasal septoplasty endoscopic surgery. In the present clinical trial, a total of 30 patients with NSD were enrolled, and DRs were calculated prior to surgery by three dimensional computer tomography (3D-CT) reconstruction techniques combined with mechanical analysis. The distribution of stress lines at the nasal septum deviation site was evaluated prior to operation. Following nasal septoplasty endoscopic surgery, pre and postoperation scores for VAS and NAR were compared. The results demonstrated that DR was significantly correlated with preoperational NAR (r=0.534) and VAS scores (r=0.397). According to preoperative CT measurements of NSD, DR and biomechanical properties, selective excision was performed to remove core areas of stress. It was observed that postoperative DR, NAR and VAS scores were significantly lower (all P<0.01) than those measured preoperation. Furthermore, over a follow-up period of 3 months, 23 cases (73.1%) were cured and 7 cases (23.3%) exhibited improvements. These results indicate that preoperative measurement of septum DR by 3D-CT reconstruction techniques may be important in determining the specific surgical approach of nasal septoplasty required.

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Cleft lip, nose, and palate: the nasal septum as the pacemaker for midfacial growth

Cited by 60 publications

References 24 publications

Unilateral cleft lip/nose repair using an equal bows /straight line advancement technique – A preliminary report and postoperative symmetry-based anthropometry

Unilateral cleft lip/nose repair using an equal bows /straight line advancement technique – A preliminary report and postoperative symmetry-based anthropometry

Peculiarities of the Upper Lip Morphogenesis and Its Relation to Facial Development

Measurement of deformation rate in nasal septum deviation by three-dimensional computer tomography reconstruction and its application in nasal septoplasty endoscopic surgery

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