Cleft Palate Repair, Gingivoperiosteoplasty, and Alveolar Bone Grafting

Dao, Ashley M.; Goudy, Steven L.

doi:10.1016/j.fsc.2016.06.005

Cited by 33 publications

(24 citation statements)

References 29 publications

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“…A variety of well-established CL and palatoplasty techniques are available and are dictated by the severity of clefting in individuals. CP repair, in general, is dependent upon the principles of a tension-free and multilayered closure with repositioning of the velar muscle sling (Dao and Goudy 2016). The consensus for the optimum timing of intervention falls between 10 and 12 mo of age (Liao and Mars 2006) but most customarily within 18 mo.…”

Section: Postnatal Surgical Correction Of Cleft Palate Defectsmentioning

confidence: 99%

Molecular Diagnostics and In Utero Therapeutics for Orofacial Clefts

et al. 2020

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Orofacial clefts and their management impose a substantial burden on patients, on their families, and on the health system. Under the current standard of care, affected patients are subjected to a lifelong journey of corrective surgeries and multidisciplinary management to replace bone and soft tissues, as well as restore esthetics and physiologic functions while restoring self-esteem and psychological health. Hence, a better understanding of the dynamic interplay of molecular signaling pathways at critical phases of palate development is necessary to pioneer novel prenatal interventions. Such pathways include transforming growth factor–β ( Tgfβ), sonic hedgehog ( Shh), wingless-integrated site ( Wnt)/β-catenin, bone morphogenetic protein ( Bmp), and fibroblast growth factor ( Fgf) and its associated receptors, among others. Here, we summarize commonly used surgical methods used to correct cleft defects postnatally. We also review the advances made in prenatal diagnostics of clefts through imaging and genomics and the various in utero surgical corrections that have been attempted thus far. An overview of how key mediators of signaling that drive palatogenesis are emphasized in the context of the framework and rationale for the development and testing of therapeutics in animal model systems and in humans is provided. The pros and cons of in utero therapies that can potentially restore molecular homeostasis needed for the proper growth and fusion of palatal shelves are presented. The theme advanced throughout this review is the need to develop preclinical molecular therapies that could ultimately be translated into human trials that can correct orofacial clefts at earlier stages of development.

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Section: Postnatal Surgical Correction Of Cleft Palate Defectsmentioning

confidence: 99%

Molecular Diagnostics and In Utero Therapeutics for Orofacial Clefts

et al. 2020

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“…Secondary alveolar graft is performed between the ages of 5 and 13 and is usually based on dental rash. And the late graft after the age of 13 [5].…”

Section: Introductionmentioning

confidence: 99%

“…This concept gained popularity because at the same time they addressed both soft tissues and bone defi cit and creates the possibility of harmonious facial growth and development. (12) Advantages include early stabilization of alveolar segments and improved arc shape, although alterations in the growth of the facial middle third have led to the abandonment of primary graft in several treatment centers [5].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, it is considered that 75% to 90% of the dimensions of adult jaws are reached at 5 years. Therefore, it is possible that maxillary growth will not be signifi cantly altered if the graft was performed at that time [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The image is essential and typically a panoramic x-ray is satisfactory. A medical-grade CT scan is not recommended [5]. Mars, et al (1987) published a method called GOSLON (Great Ormond Street, London and Oslo) criterion to rate the outcome of treatment in patients with HPL.…”

Section: Introductionmentioning

confidence: 99%

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Radiographic evaluation of secondary alveolar graff in the closure of alveolar fissures of patients with cleft lip and palate

C¹,

Roberto²

2020

Int J Oral Craniofac Sci

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The X-ray evaluation of alveolar bone graft in lip-toveal palatines is one of the relevant topics in the management of this type of pathology since there are several studies conducted with parameters that are taken to determine the timing of the graft and its feasibility, as well as fi nd the most accurate form and measure the integration of grafting dares of radiographic studies. Objective: to measure the radiographic integration of secondary alveolar graft in the closure of alveolar fi ssures of patients with cleft lip and palate.

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