Click-Reaction-Mediated Chemotherapy and Photothermal Therapy Synergistically Inhibit Breast Cancer in Mice

Zhang, Guiquan; Chen, Xu; Du, Kaihong; Ding, Keke; He, Dong; Hu, Rong; Qin, Anjun; Tang, Ben Zhong

doi:10.1021/acsnano.3c03005

Cited by 24 publications

(7 citation statements)

References 54 publications

(71 reference statements)

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“…ICD could release TAAs and DAMPs for priming the downstream immune responses. [ 28,29 ] Thus, we investigated adenosine triphosphate (ATP) and high mobility group box 1 protein (HMGB1) releasing, two key DMAPs for ICD effects, by ATP assay kit and ELISA analysis, respectively. We first confirmed that SAB could not induced ICD at selected concentrations (Figures S9 and S10, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Strategy Based on High Clinical Translational Nanosystem for Programmable Immunotherapy of Triple Negative Breast Cancer

Meng,

Wu,

Feng

et al. 2024

Advanced Materials

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Triple negative breast cancer (TNBCs), known as an immunologically cold tumor, is difficult to completely eliminate with existing monotherapies, let alone metastasis and recurrence. It is urgent to design a rational combination of multiple therapies to programmatically reconstitute tumor microenvironment (TME) and reverse the immune “cold” into “hot” inflammatory tumors to improve the therapeutic effect. Hence, in this work, a multifunctional nanosystem (FeSH NPs) that integrates metal‐polyphenol coordination complex as a photothermal agent and polyphenol, salvianolic acid B (SAB) as immunomodulator is designed and fabricated for synergistic photothermal‐immunotherapy of TNBCs combined with anti‐PD‐L1 antibody. Guided by photothermal/photoacoustic dual‐mode imaging, photothermal therapy (PTT) caused by FeSH NPs induces immunogenic cell death (ICD) under 808 nm laser irradiation. Subsequently, the loaded SAB is released with the addition of deferoxamine mesylate (DFO) to remodel TME, specifically TGF‐β inhibition and PD‐L1 upregulation, and eliminate the primary tumors. The combination of PTT and TME reprogramming by FeSH NPs further synergizes with anti‐PD‐L1 antibody to eradicate recurrence and inhibit metastasis of TNBCs concurrently. Given the biosafety of FeSH NPs throughout the lifecycle, this work provides a protocol with high clinical translational promise for comprehensive programmed therapeutics of immunologically cold tumors TNBCs.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

A Comprehensive Strategy Based on High Clinical Translational Nanosystem for Programmable Immunotherapy of Triple Negative Breast Cancer

Meng,

Wu,

Feng

et al. 2024

Advanced Materials

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“…Then, the phototherapeutic effect of PYT NPs on tumor cells was assessed with standard cell counting kit-8 (CCK-8) assays (Fig. 3 a) in vitro [ 45 , 46 ]. In order to investigate the biological safety of PYT NPs, dark toxicity experiments of PYT NPs (at 0–50 μg mL −1 ) for three tumor cell lines, including 4T1, HeLa and B16F10, were investigated (Additional file 1 : Fig.…”

Section: Resultsmentioning

confidence: 99%

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

Xie,

Wang,

Zeng

et al. 2023

J Nanobiotechnol

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Photothermal therapy (PTT) and photodynamic therapy (PDT) are effective method for tumor treatment. However, the limited variety and quantity of photothermal agents (PTAs) and photosensitizer (PSs) are still major challenges. Moreover, the cell apoptosis mechanism induced by PDT and PTT is still elusive. A fused-ring small molecule acceptor–donor acceptor′ donor–acceptor (A-DA′D-A) type of Y5 (Scheme 1) has a narrow band-gap and strong light absorption. Herein, we used Y5 to polymerize with thiophene unit to obtain polymer PYT based on polymerized small molecule strategy, and PYT nanoparticles (PYT NPs) was prepared via one-step nanoprecipitation strategy with DSPE-PEG2000. PYT NPs had excellent biocompatibility, good photostability, high photothermal conversion efficiency (67%) and reactive oxygen species (ROS) production capacity under 808 nm laser irradiation (PYT NPs + NIR). In vitro and in vivo experiments revealed that PYT NPs + NIR had the ability to completely ablate tumor cells. It was demonstrated that cell apoptosis induced by PYT NPs + NIR was closely related to mitochondrial damage. This study provides valuable guidance for constructing high-performance organic PTAs and PSs for tumor treatment.

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“…Photothermal therapy (PTT) involves irradiation of light-absorbing agents accumulated in the tumor with light to convert optical energy into heat for thermal ablation of cancer cells. Theoretically, photothermal agents are non-toxic in the dark, but turn to be toxic to tumor cells upon the local applied light, leading to high treatment efficacy for all types of tumors with few side effects [ 7 – 12 ]. However, conventional photothermal therapy alone is not sufficient to completely eradicate tumors, leaving residual tumor margins and resulting in tumor recurrence.…”

Section: Introductionmentioning

confidence: 99%

Laser-activable murine ferritin nanocage for chemo-photothermal therapy of colorectal cancer

Cheng,

Li,

et al. 2024

J Nanobiotechnol

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Chemotherapy, as a conventional strategy for tumor therapy, often leads to unsatisfied therapeutic effect due to the multi-drug resistance and the serious side effects. Herein, we genetically engineered a thermal-responsive murine Ferritin (mHFn) to specifically deliver mitoxantrone (MTO, a chemotherapeutic and photothermal agent) to tumor tissue for the chemotherapy and photothermal combined therapy of colorectal cancer, thanks to the high affinity of mHFn to transferrin receptor that highly expressed on tumor cells. The thermal-sensitive channels on mHFn allowed the effective encapsulation of MTO in vitro and the laser-controlled release of MTO in vivo. Upon irradiation with a 660 nm laser, the raised temperature triggered the opening of the thermal-sensitive channel in mHFn nanocage, resulting in the controlled and rapid release of MTO. Consequently, a significant amount of reactive oxygen species was generated, causing mitochondrial collapse and tumor cell death. The photothermal-sensitive controlled release, low systemic cytotoxicity, and excellent synergistic tumor eradication ability in vivo made mHFn@MTO a promising candidate for chemo-photothermal combination therapy against colorectal cancer. Graphical Abstract

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Click-Reaction-Mediated Chemotherapy and Photothermal Therapy Synergistically Inhibit Breast Cancer in Mice

Cited by 24 publications

References 54 publications

A Comprehensive Strategy Based on High Clinical Translational Nanosystem for Programmable Immunotherapy of Triple Negative Breast Cancer

A Comprehensive Strategy Based on High Clinical Translational Nanosystem for Programmable Immunotherapy of Triple Negative Breast Cancer

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

Laser-activable murine ferritin nanocage for chemo-photothermal therapy of colorectal cancer

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