'Click' synthesized non-substituted triazole modified chitosan from CaC2 as a novel antibacterial and antioxidant polymer

D., Pal Manisha; Chawla, Ruchi; Dutta, Parikshit

doi:10.1007/s10965-022-03032-3

Cited by 7 publications

(1 citation statement)

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“…Chitosan triazole derivatives were modified by Wolff cyclocondensation between the chitosan amine group and α -diazo- β -oxoamides [ 52 ]. Chitosan amine and unsubstituted acetylene were converted to triazole moieties on chitosan by a click reaction [ 53 ].…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Quaternary and Protonable Basic Chitotriazolans: Synthesis by Click Chemistry Conversion of Chitosan Azides and Investigation of Antibacterial Activity

Rathinam,

Magdadaro,

Hjálmarsdóttir

et al. 2024

JFB

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The azide transfer reaction and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) can be used to convert the amino groups in chitosan to triazole 1,2,3-moieties. The resulting polymer has been named chitotriazolan. This synthesis was performed with six different quaternary ammonium alkynes and three amine alkynes to obtain a series of nine water-soluble chitotriazolan derivatives. The structure and complete conversion of the azide were confirmed by FT-IR and proton NMR spectroscopy. The derivatives were investigated for antibacterial activity against S. aureus, E. faecalis, E. coli, and P. aeruginosa. The activity of the quaternized chitotriazolan derivatives varied depending on the structure of the quaternary moiety and the species of bacteria. The basic protonable derivatives were less active or inactive against the bacteria.

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Section: Introductionmentioning

confidence: 99%