Clickable Multifunctional Large-Pore Mesoporous Silica Nanoparticles as Nanocarriers

Chiu, Hsin-Yi; Gößl, Dorothée; Haddick, Lisa; Engelke, Hanna; Bein, Thomas

doi:10.1021/acs.chemmater.7b03472

Cited by 34 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, MSNPs can be PEGylated on the outer surface via a mercapto-reactive maleimide-PEG linker. In this case, the inner surface of the MSNPs was modified with aza-dibenzocy-clooctyne derivatives to enable copper-free “click” chemistry reactions for the conjugation of azide-terminated cargos [ 109 ]. Another example is the PEGylation of AuNPs via grafting-to approach, which can be performed using thiolated PEG molecules [ 110 ].…”

Section: Core-brush Nanoparticlesmentioning

confidence: 99%

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

2018

View full text Add to dashboard Cite

Hybrid nanomaterials based on inorganic nanoparticles and polymers are highly interesting structures since they combine synergistically the advantageous physical-chemical properties of both inorganic and polymeric components, providing superior functionality to the final material. These unique properties motivate the intensive study of these materials from a multidisciplinary view with the aim of finding novel applications in technological and biomedical fields. Choosing a specific synthetic methodology that allows for control over the surface composition and its architecture, enables not only the examination of the structure/property relationships, but, more importantly, the design of more efficient nanodevices for therapy and diagnosis in nanomedicine. The current review categorizes hybrid nanomaterials into three types of architectures: core-brush, hybrid nanogels, and core-shell. We focus on the analysis of the synthetic approaches that lead to the formation of each type of architecture. Furthermore, most recent advances in therapy and diagnosis applications and some inherent challenges of these materials are herein reviewed.

show abstract

Section: Core-brush Nanoparticlesmentioning

confidence: 99%

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

2018

View full text Add to dashboard Cite

show abstract

“…This design resulted into a high ionic rectification and ion gating via pH‐responsive groups. Bein and co‐workers [ 34 ] reported multifunctional mesoporous silica nanoparticles to create a drug delivery system with controlled cargo release by using redox‐ or pH‐sensitive groups. Although first examples of local functionalization of pores as well as multifunctionalization of surfaces are described, typically both concepts are not combined and local placement of different functional units inside one pore has not been accomplished.…”

Section: Introductionmentioning

confidence: 99%

Wetting‐Controlled Localized Placement of Surface Functionalities within Nanopores

Ochs

Mohammadi²,

Vogel³

et al. 2020

Small

View full text Add to dashboard Cite

Mimicking such functional control in synthetic nanopores requires precise control of structure and local placement of surface functionality. Such precisely prepared materials with nanoscale control on structure and functionalization would allow, for example, new perspectives in sensing. [1] Further strategies mimicking the functionality of biological channels include dynamic curvature nanochannel-based membranes to regulate ionic transport [2] or flexible elastomer-based microchannels for microfluidic devices. [3] Already today nanoscopically structured materials play a crucial role in applications such as sensors or lab on chip devices, [4] separation, [4d] catalysis, [5] and for the developing of new materials, for example for applications in tissue engineering [6] or for the control of surface wettability. [7] Traditionally, nanostructures are fabricated using top-down approaches like photolithography, ink-jet printing or electrospinning. Alternatively, bottom-up methods, which are based on the self-assembly of molecules or larger building blocks, can yield defined structures with high resolution. [8] Periodic, nanostructured materials are for example accessible through the self-assembly of colloidal building blocks, which can yield macroscopic areas of wellordered colloidal crystals. [9] Such colloidal crystals can be further used as templates to generate inorganic, interconnected nanopore arrays by backfilling with a sol-gel precursor and subsequent removal of the templating particles. [9a,10] In two dimensions, the resulting porous materials are known as inverse colloidal monolayers and their wettability can be adjusted by pore opening angle and surface functionalization. [7e,11] Such structures are ideal model pores due to their uniformity, adjustable pore size and ordered structure.A key step toward multifunctional nanopores with nanolocal control, is the ability to precisely position different functionalities into individual pores. [1a] Therefore, it is necessary to develop strategies for a nanoscale control in manufacturing and functionalization of porous materials. This enables nanopore design with multiple functional and responsive units, individually and precisely placed into each nanopore. [1b] To date, functionalization of porous silica materials is mainly based on postsynthetic functionalization strategies like grafting of silanes from gas or liquid phase or cocondensation of functional building blocks. [12] These approaches generally result in a homogenous functionalization without In the context of sensing and transport control, nanopores play an essential role. Designing multifunctional nanopores and placing multiple surface functionalities with nanoscale precision remains challenging. Interface effects together with a combination of different materials are used to obtain local multifunctionalization of nanoscale pores within a model pore system prepared by colloidal templating. Silica inverse colloidal monolayers are first functionalized with a gold layer to create a hybrid porous ...

show abstract

“…Ordered MSNs are often synthesized using TEOS (tetraetoxysilane) as a silica source and ionic (for e.g., MCM-41 systems) or non-ionic (for SBA-15 systems) surfactants governing inorganic-organic mesophase formation [6]. It has been reported that the size and shape of MSNs can be easily tailored by varying the temperature [7,8], reactants ratio [9], pH [10], surfactant chain length [11], as well as the addition of functional organosilanes [12]. Properly tailored MSNs found applications in numerous fields such as drug delivery systems [13,14], wastewater treatment [15,16], catalysis [17,18], fabrication of nanoreactors [19,20] and nanocontainers [21,22].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

2020

View full text Add to dashboard Cite

Spherical silica nanoparticles with solid cores and mesoporous shells (SCMS) were decorated with thermoresponsive polymer brushes that were shown to serve as macromolecular valves to control loading and unloading of a model dye within the mesopores. Thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) brushes were grafted from the surfaces of both solid core (SC) and SCMS particles of similar size using surface-initiated atom transfer radical polymerization. Both systems based on porous (SCMS-PNIPAM) and nonporous (SC-PNIPAM) particles were characterized using cryo-TEM, thermogravimetry and elemental analysis to determine the structure and composition of the decorated nanoparticles. The grafted PNIPAM brushes were found to be responsive to temperature changes enabling temperature-controlled gating of the pores. The processes of loading and unloading in the obtained systems were examined using a model fluorescent dye—rhodamine 6G. Polymer brushes in SCMS-PNIPAM systems were shown to serve as molecular valves enabling significant adsorption (loading) of the dye inside the pores with respect to the SC-PNIPAM (no pores) and SCMS (no valves) systems. The effective unloading of the fluorescent cargo molecules from the decorated nanoparticles was achieved in a water/methanol solution. The obtained SCMS-PNIPAM particles may be used as smart nanocontainers or nanoreactors offering also facile isolation from the suspension due to the presence of dense cores.

show abstract

Clickable Multifunctional Large-Pore Mesoporous Silica Nanoparticles as Nanocarriers

Cited by 34 publications

References 36 publications

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

Wetting‐Controlled Localized Placement of Surface Functionalities within Nanopores

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

Contact Info

Product

Resources

About