The persistent theme contending that relational factors are relevant to the outcome of behavior therapy necessitated the replication with adequate controls of a previous study by these authors. The aim of the study was to explore the relevance to the outcome of desensitization of same-sex and opposite-sex pairings of subjects and experimenters. Twelve groups, consisting of all subjectexperimenter same-or opposite-sex combinations were employed. Confirming the findings of the earlier work that subject-experimenter sex pairing is irrelevant, the study, however, revealed significant differences between the pseudodesensitization and the no treatment control groups. It was concluded that the inclusion of pseudodesensitization groups in experimental studies is imperative, and that the role of relational factors is by no means a closed issue.