Autoimmune hepatitis (AIH), which tends to develop in middleaged women, is a chronic and progressive disease that causes hepatocellular injury. 1 Viral hepatitis accounted for most hepatic diseases in Asia, and AIH was considered a relatively rare disease. Therefore, almost all epidemiological studies of AIH were conducted in Europe and the USA. However, in recent years, the importance of improved disease awareness and enhanced management for AIH has increased in Asia, resulting in several epidemiological studies. This review explains future management and countermeasures by compiling the current situation of AIH in various regions in Asia.
| G ENER AL CHAR AC TERIS TI C S OF AIHWhen the liver injury is significant, AIH is exhibited by non-specific symptoms, such as general malaise and inappetence, and icterus and ascites can occur with severe liver injury. On the other hand, many cases do not exhibit symptoms, and liver injury is coincidentally discovered during medical checkups or in the course of other diseases. AIH is characterized by hepatocellular injury, elevated serum transaminase levels, autoantibody-positive for anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-soluble liver antigen-antibody and elevated serum IgG level, 1 which usually exceeds 2000 mg/dl in most cases. In particular, that the IgG level is sometimes low in the early stage of acute-onset cases.