“…This effect estimate derives from a single-pollutant model, without adjustment for PM 2.5 concentration, and has also been applied in the Global Burden of Disease (GBD) project (Forouzanfar et al, 2016), albeit using the annual maximum of the three-month running mean of the daily maximum 1-hour ozone concentration, rather than the corresponding six-month metric, to account for global variation in the timing of the peak ozone season (Brauer et al, 2016, Cohen et al, 2017. A large number of studies have used exposure-response coefficients derived by Jerrett et al (2009) for estimating global and regional respiratory-related mortality associated with long-term exposure to ozone Anenberg et al, 2010Anenberg et al, , 2012Lim et al, 2012;Fang et al, 2013;Silva et al, 2013Silva et al, , 2016Forouzanfar et al, 2015Forouzanfar et al, , 2016Shindell et al, 2012Shindell et al, , 2016. For example, the most recent GBD Study (Forouzanfar et al, 2016) estimated that 254,000 chronic obstructive pulmonary disease (COPD)-related deaths globally were attributable to ambient ozone exposure in 2015, an increase of 19% since 2005.…”