Global large-scale urbanization and climate change have become indisputable scientific facts yet are unresolved issues, and are a common concern for mankind. The relationship between these two topics is unclear and it is not known how to deal appropriately at the scientific level with climate change in the process of urbanization. Further exploration of the science, management and practice, are needed to achieve global and regional sustainadevelopment. This paper first considers the basic facts concerning mass urbanization and climate change and summarizes the interactions and possible mechanisms of urbanization and climate change. Urbanization leads to the heat island effect, an uneven distribution of precipitation and extreme weather, together with a local-regional-global multi-scale superposition effect, which aggravates the consequences of global climate change. The impact of climate change on urbanization is mainly manifested in aspects such as changes of energy consumption, mortality, and the spread of infectious diseases, sea level rise, extreme weather damage to infrastructure, and water shortages. This paper also briefly reviews relevant international research programs and action coalitions and puts forward an analysis framework multi-dimensional sustainable urbanization which can adapt to and mitigate climate change, from the perspective of the four key dimensions-population, land use, economy, and society. It is imperative that we strengthen the interdisciplinary activities involving the natural and social sciences, take urbanization and other human activities into consideration of the landatmosphere system, and explore the human-land-atmosphere coupling process. The adaptation and mitigation from the perspective of human activities, as represented by urbanization, might be the most critical and realistic way to deal with climate change.