This study analyses the awareness level of key stakeholders about climate change impacts on the tourism sector in the Mekong Delta. In the regional context, stakeholders include tourism authorities, tourism businesses and tourists. The study investigates the following aspects of climate change awareness in the tourism sector in the region: 1) the climate change knowledge of tourism authorities, tourism businesses and tourists; 2) sources of awareness as well as quality of these sources; 3) climate change awareness education and action. As well as descriptive statistics, means and significant analysis, cross tabulation analysis is also used in this study to compare the awareness between stakeholder groups. The study found that the awareness level of tourism stakeholders in the region is at stage two of environmental awareness model of Partanen-Hertell et al. (Partanen-Hertell, Harju-Autti, Kreft-Burma, & Pemberton, 1999).