<b><i>Introduction:</i></b> It is now crystal clear that weather change is not just a fact but a circumstance that threatens to be extremely destructive. It has a quantifiable negative impact on human well-being, physical and mental health. Therefore, this review was conducted with an aim to study the global actions on climatic changes with a special focus on health of the population, health systems, and their preparedness. <b><i>Methods:</i></b> The writing of this systematic review followed the guidance of PRISMA checklist. Extensive literature research was conducted at the sources of information which included MEDLINE (PubMed interface), and Google Scholar, to identify articles discussing the role of climatic change and its impacts. <b><i>Results:</i></b> It was found that many challenges to health sector are posed by the climatic changes; therefore, public health preparedness and response should be upgraded through strategy adaptation, risk mitigation, and assessment measures. <b><i>Conclusion:</i></b> Discoveries on key health changes and climatic indicators aimed toward informed decisions by policy makers about policy programs implementation, detect evidence gaps, and better recognition of the barriers in achieving the health system adaptability and resilience, thereby maximizing the health problems caused by climate change around the globe.