Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist

Belzer, Annika; Parker, Eva Rawlings

doi:10.1007/s40257-023-00770-y

Cited by 19 publications

(5 citation statements)

References 95 publications

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“…Increased levels of UV radiation (UVR) caused by stratospheric ozone depletion can cause DNA damage to keratinocyte cells, which is strongly associated with the development of cSCC. Increased temperatures caused by global warming can lead to increased time spent outdoors and less clothing, which alters the diversity of microorganisms on the skin and exacerbates inflammation caused by exposure to UVR [ 44 ]. However, a limited number of studies has made it challenging to develop suitable policies for the Chinese population concerning understanding the impact of UVR doses on skin health.…”

Section: Discussionmentioning

confidence: 99%

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Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

Huang,

Jiang,

Wong

et al. 2024

J Glob Health

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Background China has the highest number of new cancer cases and deaths globally. Due to particularly low scores in health care quality for cutaneous squamous cell carcinoma (cSCC), the country’s cSCC burden requires greater awareness. Consequently, we aimed to evaluate and predict the trend of the cSCC burden globally and in China from 1990 to 2030. Methods We retrieved data from the Global Burden of Disease 2019 study, which provided estimates of the incidence, mortality, prevalence, and disability-adjusted life years (DALYs) of cSCC from 1990 to 2019. We set up joint-point analyses and Bayesian age-period-cohort (BAPC) models to predict the disease burden of cSCC up to 2030. Results In 2019, China reported age-standardised rates of cSCC prevalence, incidence, mortality, and DALYs of 2.54, 2.12, 0.88, and 16.76 per 100 000 population, respectively. The country’s prevalence and incidence rates from 1990 to 2019 were lower than the global levels, but its mortality and DALY rates were higher. The age-standardised rates were higher for males, and the disease burden increased with each age group globally and in China. Moreover, the average annual percentage change showed all indicators were growing faster than the global levels. According to the BAPC model, there will be an upward trend in the prevalence and incidence globally and in China between 2020 and 2030, with a decrease in mortality and DALYs. Conclusions We observed an upward trend in the cSCC burden over the past 30 years in China. Prevalence and incidence are expected to continue at a higher rate than the global average in the next decade, while mortality and DALYs are predicted to decrease. As the Chinese population ages, efforts toward managing and preventing cSCC should be targeted towards the elderly population.

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Section: Discussionmentioning

confidence: 99%

“…Despite this, our understanding of cSCC remains lacking, as studies on its epidemiology had mostly analysed it in combination with other skin tumours. Factors including the ageing population, climatic changes, and economic fluctuations may influence the burden [ 42 , 44 , 45 ].…”

mentioning

confidence: 99%

Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

Huang,

Jiang,

Wong

et al. 2024

J Glob Health

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“…The human skin is constantly exposed to a multitude of stressors that can negatively impact its health and appearance. Factors such as climate change [1], environmental pollutants [2], sunlight [3], and imbalances in the skin's microbiota [4] can accelerate the development of undesirable cutaneous alterations. These modifications often manifest as dryness, changes in texture, an oily complexion, hyperpigmentation, redness, telangiectasia, and keratosis [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Topically Applied Magnetized Saline Water Improves Skin Biophysical Parameters Through Autophagy Activation: A Pilot Study

Minoretti,

Santiago Sáez,

Liaño Riera

et al. 2023

Cureus

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Background Water exposed to a magnetic field exhibits several changes in its properties, such as increased electrical conductivity, reduced density, and low surface tension. Additionally, it has reduced dissolved oxygen levels and becomes more alkaline. Previous experimental studies have demonstrated that exposure to saline alkaline water leads to a dose-dependent increase in the expression of autophagy-related genes. Here, we hypothesize that the topical application of magnetized alkaline water to the skin can activate autophagy and improve cutaneous biophysical parameters, making it a promising strategy for enhancing skin aesthetics. Methods Two distinct substudies were undertaken. Firstly, a 12-week, uncontrolled, open-label investigation was conducted with 20 females who desired to enhance the appearance of their facial and neck skin. Secondly, a molecular study was carried out on a subset of 10 females to investigate the serum’s impact on two autophagy markers (Beclin-1 and mammalian/mechanistic target of rapamycin {mTOR}) in skin biopsies taken from the posterior neck area below the hair attachment line. Results After a period of 12 weeks, the application of the serum resulted in significant improvements in skin hydration within the stratum corneum (56 ± 14 arbitrary units {a.u.}) compared to the baseline measurement (47 ± 12 a.u.; p < 0.001). Moreover, the transepidermal water loss (TEWL) decreased from 14 ± 2 g/m 2 /hour to 11 ± 3 g/m 2 /hour (p < 0.001). The results also revealed a notable reduction in sebum content from 38 ± 7 µg/cm 2 to 30 ± 4 µg/cm 2 after the 12-week period of serum application (<0.001). Additionally, the melanin index (p < 0.01) and erythema index (p < 0.001) were both significantly lower at 12 weeks compared to baseline. The molecular study showed a 38% increase in Beclin-1 levels after 12 weeks of serum application on the posterior neck area, as measured from skin biopsies. In contrast, mTOR levels decreased by 24% from baseline to 12 weeks. Conclusion The application of magnetized saline water topically, within a serum formulation, shows potential in improving skin biophysical parameters for females seeking to enhance the appearance of their facial and neck skin. These beneficial effects are achieved through the activation of cutaneous autophagy, as evidenced by an increase in Beclin-1 expression and a decrease in mTOR content in the skin.

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“…For example, stratospheric ozone depletion is mainly caused by ultraviolet (UV) exposure, which increases the risk of melanoma and keratinocyte carcinoma, and it is also reported to be associated with increased air pollution. Related skin diseases are atopic dermatitis, psoriasis, pemphigus, acne, melasma, and photoaging [7,8]. In addition, as the global pandemic continues, awareness of the resulting economic downturn and environmental issues is growing.…”

Section: Introductionmentioning

confidence: 99%

Sustainable Countermeasures for Skin Health Improvement for Green Consumers: The Utilization of Hsian-Tsao during Global Warming

Lee,

Kwon

2023

Sustainability

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Recently, the seriousness of global warming has become increasingly prominent worldwide. In this study, Hsian-tsao, a safe, heat-resistant ingredient that can be eaten and applied, and its extract products were examined for their potential applicability as a countermeasure for problems that may arise in the skin due to global warming. This includes being flexible and responsive to changes in consumer demand due to global warming. Furthermore, regarding global warming, the scientific community is considering ways to mitigate heat stress in humans and animals, and we hope to provide key data for future exploration. Although this review is a narrative review, we conducted a systematic review and searched sources such as PubMed, Medline, Scopus, ResearchGate, and Google Scholar according to PRISMA flow chart guidelines and using a chain of search words such as “global warming”, “green industry”, “Hsian-tsao”, “heat resistance”, “skin health”, “cosmetics”, and “consumer”. Accordingly, we searched a total of 1231 studies and selected 107 studies in the final stage. Considering the sustainability and safeness of Hsian-tsao, further studies to help mitigate human heat stress caused by global warming and evaluate its impact on beauty and health should analyze its utilization and reflect consumer needs that can contribute to the green industry. Therefore, in a situation where the growth of the green industry is urgently needed due to the acceleration of global warming, additional research is necessary on inner-beauty materials and heat-resistant plants that lower the temperature in line with future preparations for continuous global warming. Accordingly, the science community and nutrition, inner beauty, and cosmetics industries seem likely to bring more interest to the green industry, and this trend will continue in the future. We hope that Hsian-tsao will be used in a variety of skin health strategies and nutritional approaches to global warming and heat resistance.

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Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist

Cited by 19 publications

References 95 publications

Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

Topically Applied Magnetized Saline Water Improves Skin Biophysical Parameters Through Autophagy Activation: A Pilot Study

Sustainable Countermeasures for Skin Health Improvement for Green Consumers: The Utilization of Hsian-Tsao during Global Warming

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