The risk of extreme climatic conditions leading to unusually low global agricultural production is exacerbated if more than one global 'breadbasket' is subject to climatic extremes at the same time. Such shocks can pose a risk to the global food system amplifying threats to global food security 1,2 and have the potential to trigger other systemic risks 3,4. So far, while the possibility of climatic extremes hitting more than one breadbasket has been postulated 5,6 little is known about the actual risk. Here we present quantitative risk estimates of simultaneous breadbasket failures due to climatic extremes and show how risk has changed over time. We combine region-specific data on agricultural production with spatial statistics of climatic extremes to quantify the changing risk of low production for the major food producing regions ('breadbaskets') in the world. We find evidence that there is increasing risk of simultaneous failure of wheat, maize and soybean crops, across the breadbaskets analyzed. For rice, risks of simultaneous adverse climate conditions have decreased in the breadbaskets analyzed in this study in the recent past mostly owing to solar radiation changes favoring rice growth. Depending on the correlation structure between the breadbaskets, spatial dependence between climatic extremes globally can mitigate or aggravate the risks for the global food production. Our analysis can provide the basis for more efficient allocation of resources to contingency plans and/or strategic crop reserves that would enhance the resilience of the global food system. Climate variability explains at least 30% of year-to-year fluctuations in agricultural yield 7. Under 'normal' climatic circumstances the global food system can compensate local crop losses through grain storage and trade 8. However, it is doubtful whether the global food system is resilient to more extreme climatic conditions 9 , when export restrictions 10 and diminished grain stocks may undermine liquidity in agricultural commodity markets, resulting in higher price volatility. The food price crisis in 2007/08 has shown that climatic shocks to agricultural production contribute to food price spikes 1 and famine 2 , with the potential to trigger other systemic risks including political unrest 3 and migration 4. Climatic teleconnections between global phenomena such as El Niño Southern Oscillation (ENSO) and regional climate extremes such as Indian heatwaves 11 or flood risks around the globe 12 could lead to simultaneous crop failure in different regions, therefore posing a risk to the global food system 8,10 , and amplifying threats to global food security. While the possibility of a climatic extreme hitting more than one breadbasket has been a growing cause for concern 5,6 , only few studies have investigated the probability of simultaneous production shocks 13 or estimated the joint likelihoods of adverse climate conditions 14. Here we present, to our knowledge for the first time, quantitative risk estimates of simultaneous breadbasket failures due...