Climate-mediated air pollution associated with COPD severity

Tran, Huan Minh; Chen, Tzu-Tao; Lu, Yueh‐Hsun; Tsai, Feng Jen; Chen, Kuan-Yuan; Ho, Shu-Chuan; Wu, Chih-Da; Wu, Sheng‐Ming; Lee, Yueh-Lun; Chung, Kian Fan; Kuo, Han‐Pin; Lee, Kang‐Yun; Chuang, Hsiao-Chi

doi:10.1016/j.scitotenv.2022.156969

Cited by 18 publications

(11 citation statements)

References 58 publications

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“…Nevertheless, 30‐day exposure to PM2.5, PM10, SO2, CO, and NO2 has been positively correlated with LM scores but negatively correlated with LK scores. These negative correlations appear counterintuitive, especially when considering that the lower‐airway literature demonstrates positive correlations between pollution and disease severity 31,32 . There may be several possible explanations for these observations.…”

Section: Discussionmentioning

confidence: 97%

“…These negative correlations appear counterintuitive, especially when considering that the lower-airway literature demonstrates positive correlations between pollution and disease severity. 31,32 There may be several possible explanations for these observations. It is possible that certain subtypes of CRS with a predominantly SO2-or CO-driven pathophysiology are more amenable to clinical improvement following surgery compared with other disease phenotypes.…”

Section: Discussionmentioning

confidence: 99%

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Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?

Hagedorn

Tullis

Nguyen

et al. 2023

Int Forum Allergy Rhinol

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BackgroundPoor air quality increases the risk of developing chronic rhinosinusitis (CRS) and other airway diseases. However, there are limited data on air pollutants and CRS‐specific disease severity. We assessed the impact of air pollutants on sinonasal‐specific and general quality‐of‐life (QOL) measures in a multi‐institutional cohort of patients with CRS.MethodsParticipants with CRS were prospectively enrolled in a cross‐sectional study and self‐selected continued appropriate medical therapy or endoscopic sinus surgery (ESS). The 22‐item SinoNasal Outcome Test (SNOT‐22) and Medical Outcomes Study Questionnaire Short‐Form 6‐D (SF‐6D) health utility value scores were recorded. Patient exposure to air pollutants was determined using residence zip codes. Unadjusted group differences were compared and correlation coefficients were evaluated to identify the magnitude of bivariate association.Results486 patients were enrolled and followed for a mean of 6.9 [SD±2.3] months. Pollutant exposure did not significantly correlate with baseline SNOT‐22 or SF‐6D scores. Revision ESS was associated with higher median fine particulate matter (PM2.5; Δ = 0.12, (95% CI: 0.003, 0.234); p = 0.006) compared to primary surgery. PM2.5, PM10 and nitrogen dioxide concentrations (ug/m3) did not correlate with change in total SNOT‐22 or SF‐6D scores after treatment. Nevertheless, sulfur dioxide (SNOT‐22: ρ = ‐0.121 (95% CI: ‐0.210, ‐0.030); p = 0.007; SF‐6D: ρ = 0.095 (95% CI: 0.002, 0.186); p = 0.04) and carbon monoxide (SNOT‐22: ρ = ‐0.141 (95% CI: ‐0.230, 0.050); p = 0.002) exposure did correlate with these outcome measures.ConclusionAir pollutants may contribute, at least in part, to disease severity in CRS; future investigation is needed to further elucidate the nature of this relationship.This article is protected by copyright. All rights reserved

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?

Hagedorn

Tullis

Nguyen

et al. 2023

Int Forum Allergy Rhinol

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“…In the cumulative lag model, lag01 represents the average of the pollutant concentration on the day of admission and the day before admission, and lag07 represents the average of the pollutant concentration on the day of admission and the first 7 days before admission. Since temperature and humidity had cumulative lag effects on the number of COPD admissions, we used the sliding average of temperature and relative humidity for the N days before admission when adjusting temperature and relative humidity (Chen et al 2019b ; Konstantinoudis et al 2022 ; Tran et al 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Associations between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Jinan: potential benefits from air quality improvements

Cheng

Han

Fang

et al. 2023

Environ Sci Pollut Res

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Evidence between air pollution and chronic obstructive pulmonary disease (COPD) is inconsistent and limited in China. In this study, we aim to examine the associations between air pollutants and hospital admissions for COPD, hoping to provide practical advice for prevention and control of COPD. Hospital admissions for COPD were collected from a Grade-A tertiary hospital in Jinan from 2014 to 2020. A generalized additive model (GAM) was used to examine the associations between air pollutants and hospital admissions for COPD. Stratified analysis was also conducted for gender, age (20–74 and ≥75 years), and season (warm and cold). The avoidable number of COPD hospital admissions was calculated when air pollutants were controlled under national and WHO standards. Over the study period, a total of 4,012 hospital admissions for COPD were recorded. The daily hospital admissions of COPD increased by 2.36% (95% CI : 0.13–4.65%) and 2.39% (95% CI : 0.19–4.65%) for per 10 μg/m 3 increase of NO 2 and SO 2 concentrations at lag2, respectively. There was no statistically significant difference in health effects caused by increased concentrations of PM 2.5 , PM 10 , CO, and O 3 . The health effects of increased SO 2 concentration were stronger in women, the ≥75 years old people and the cold season. About 2 (95% CI : 0–3), 64 (95% CI : 4–132) and 86 (95% CI : 6–177) COPD admissions would be avoided when the SO 2 concentration was controlled below the NAAQS-II (150 μg/m 3 ), NAAQS-I (50 μg/m 3 ), and WHO’s AQG2021 standard (40 μg/m 3 ), respectively. These findings suggest that short-term exposure to NO 2 and SO 2 was associated with increased risks of daily COPD admissions, especially for females and the elderly. The control of SO 2 and NO 2 under the national and WHO standards could avoid more COPD admissions and obtain greater health benefits. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-023-25567-8.

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“… 29 , 30 According to a meta-analysis, with every 10μg/m 3 elevation in PM2.5, the probability of COPD-related emergency room visits and hospital admissions rose by 1.4–2.5%. 31 More PM exposure causes individuals with chronic obstructive pulmonary disease to have worse lung function, 32 , 33 lower FEV1 and oxygen saturation, more severe emphysema, 34 higher Blood Pressure, and cardiovascular mortality. 35 , 36 Furthermore, Patients with COPD are more vulnerable to pulmonary inflammation after exposure to PM2.5, especially those with poorer lung function.…”

Section: Effects Of Pm25 On Copd: Epidemiological Evidencementioning

confidence: 99%

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease

Wang¹,

Li²

2023

COPD

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Chronic obstructive pulmonary disease (COPD), a heterogeneous disease, is the leading cause of death worldwide. In recent years, air pollution, especially particulate matter (PM), has been widely studied as a contributing factor to COPD. As an essential component of PM, PM2.5 is associated with COPD prevalence, morbidity, and acute exacerbations. However, the specific pathogenic mechanisms were still unclear and deserve further research. The diversity and complexity of PM2.5 components make it challenging to get its accurate effects and mechanisms for COPD. It has been determined that the most toxic PM2.5 components are metals, polycyclic aromatic hydrocarbons (PAHs), carbonaceous particles (CPs), and other organic compounds. PM2.5-induced cytokine release and oxidative stress are the main mechanisms reported leading to COPD. Nonnegligibly, the microorganism in PM 2.5 may directly cause mononuclear inflammation or break the microorganism balance contributing to the development and exacerbation of COPD. This review focuses on the pathophysiology and consequences of PM2.5 and its components on COPD.

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Climate-mediated air pollution associated with COPD severity

Cited by 18 publications

References 58 publications

Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?

Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?

Associations between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Jinan: potential benefits from air quality improvements

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease

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