Recent studies have shown strong temporal correlations between past climate changes and societal crises. However, the specific causal mechanisms underlying this relation have not been addressed. We explored quantitative responses of 14 fine-grained agro-ecological, socioeconomic, and demographic variables to climate fluctuations from A.D. 1500-1800 in Europe. Results show that cooling from A.D. 1560-1660 caused successive agro-ecological, socioeconomic, and demographic catastrophes, leading to the General Crisis of the Seventeenth Century. We identified a set of causal linkages between climate change and human crisis. Using temperature data and climate-driven economic variables, we simulated the alternation of defined "golden" and "dark" ages in Europe and the Northern Hemisphere during the past millennium. Our findings indicate that climate change was the ultimate cause, and climate-driven economic downturn was the direct cause, of large-scale human crises in preindustrial Europe and the Northern Hemisphere.climate-driven economy | Granger Causality Analysis | grain price D ebate about the relation between climate and human crisis has lasted over a century. With recent advances in paleotemperature reconstruction, scholars note that massive social disturbance, societal collapse, and population collapse often coincided with great climate change in America, the Middle East, China, and many other countries in preindustrial times (1-5). Although most of these scientists believe that climate change could cause human catastrophe, their arguments are backed simply by qualitative scrutiny of narrow historic examples. More recent breakthroughs came from research adopting quantitative approaches to all known cases of social crisis. These studies show that, in recent history, climate change was responsible for the outbreak of war, dynastic transition, and population decline in China, Europe, and around the world because of climate-induced