“…Calculated plasma volume is very closely related to plasma viscosity; therefore, correction factors based on calculated plasma volume are often used to assess hemoconcentration [7,32]. Early researchers assumed that, under conditions of constant red cell volume, a decrease in hematocrit corresponded to a proportionally equal increase in plasma volume [33,34]. Research in the 1970s, however, suggested that hematocrit and plasma volume were not as proportional as were earlier predicted [35], and therefore hematocrit has not been shown to be directly related to plasma volume.…”