Climbers usually resident at moderate altitude exhibit less oygen desaturation during rapid ascent to 4559 m

Bernardi, Eva; Pomidori, Luca; Mandolesi, Gaia; Bartesaghi, Manuela; Cavallari, Davide; Cogo, Annalisa

doi:10.1183/13993003.congress-2015.pa2236

Cited by 1 publication

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“…It is generally thought that a strong HVR helps in performing at the extremes of high altitude, as only those individuals with a strong HVR can tolerate exposure to such altitudes without supplemental oxygen. 23 24 At the same time, it has been suggested that individuals with very strong HVR may approach their ventilatory limit at relatively lower altitudes, whereas subjects with a strong but not excessive HVR can sustain high levels of ventilation at extreme altitudes while maintaining an adequate ventilatory reserve for the summit, particularly if a relatively lower minute ventilation is compensated by a higher ventilatory efficiency. 23…”

Section: Respiratory System Responses To High-altitude Exposurementioning

confidence: 99%

High Altitude

Berger,

Luks

2023

Semin Respir Crit Care Med

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With ascent to high altitude, barometric pressure declines, leading to a reduction in the partial pressure of oxygen at every point along the oxygen transport chain from the ambient air to tissue mitochondria. This leads, in turn, to a series of changes over varying time frames across multiple organ systems that serve to maintain tissue oxygen delivery at levels sufficient to prevent acute altitude illness and preserve cognitive and locomotor function. This review focuses primarily on the physiological adjustments and acclimatization processes that occur in the lungs of healthy individuals, including alterations in control of breathing, ventilation, gas exchange, lung mechanics and dynamics, and pulmonary vascular physiology. Because other organ systems, including the cardiovascular, hematologic and renal systems, contribute to acclimatization, the responses seen in these systems, as well as changes in common activities such as sleep and exercise, are also addressed. While the pattern of the responses highlighted in this review are similar across individuals, the magnitude of such responses often demonstrates significant interindividual variability which accounts for subsequent differences in tolerance of the low oxygen conditions in this environment.

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Section: Respiratory System Responses To High-altitude Exposurementioning

confidence: 99%