2013
DOI: 10.1016/j.neuron.2013.03.018
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Climbing Fiber Input Shapes Reciprocity of Purkinje Cell Firing

Abstract: The cerebellum fine-tunes motor activity via its Purkinje cell output. Purkinje cells produce two different types of spikes, complex spikes and simple spikes, which often show reciprocal activity: a periodical increase in complex spikes is associated with a decrease in simple spikes, and vice versa. This reciprocal firing is thought to be essential for coordinated motor behavior, yet how it is accomplished is debated. Here, we show in Ptf1a::cre;Robo3(lox/lox) mice that selectively rerouting the climbing fiber… Show more

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Cited by 124 publications
(130 citation statements)
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“…Our data show that climbing fibers not only regulate the discharge of CSs but also antiphasically regulate SSs. Similar parametric antiphasic modulation of SSs by climbing fiber activity evoked by optokinetic stimulation is observed in floccular Purkinje cells (Badura et al 2013;Frens et al 2001;Graf et al 1988;Maekawa and Simpson 1973;Schonewille et al 2006).…”
Section: Brain Stem Circuitry Affected By a Ul Interferes With Vestibsupporting
confidence: 67%
See 1 more Smart Citation
“…Our data show that climbing fibers not only regulate the discharge of CSs but also antiphasically regulate SSs. Similar parametric antiphasic modulation of SSs by climbing fiber activity evoked by optokinetic stimulation is observed in floccular Purkinje cells (Badura et al 2013;Frens et al 2001;Graf et al 1988;Maekawa and Simpson 1973;Schonewille et al 2006).…”
Section: Brain Stem Circuitry Affected By a Ul Interferes With Vestibsupporting
confidence: 67%
“…6) A UL reduces modulated climbing fiber inputs primarily to contralateral folia 8 -10 and therefore impairs vestibular modulation of the discharge of CSs and SSs contralateral more than ipsilateral to the UL. 7) In mice, mutation of Ptf1a::cre;Robo3 lox/lox , the normal crossed projection of climbing fibers to the contralateral cerebellum is converted into an ipsilateral projection, leaving mossy fiber projections undisturbed (Badura et al 2013). Antiphasic discharge of CSs and SSs is maintained in these mutants, but it is directionally reversed due to the rerouted climbing fibers.…”
Section: Brain Stem Circuitry Affected By a Ul Interferes With Vestibmentioning
confidence: 99%
“…Together, these climbing-fiber-driven forms of plasticity are so prominent that selectively rerouting the climbing fibers from a contralateral to an ipsilateral projection, while maintaining the laterality of the mossy fiber system, completely reverses modulation of both Purkinje cells' simple spikes and molecular layer interneuron activity (Fig. 5) and induces dramatically ataxic motor behavior, which actually benefits from a cerebellectomy (Badura et al 2013).…”
Section: Motor Learning and The Cerebellummentioning
confidence: 99%
“…This is important for motor behavior because Purkinje cell firing influences cerebellar nuclear output (Person and Raman 2012). Thus Purkinje cell activity is central to cerebellar function and the control of movement (Badura et al 2013;Chaumont et al 2013;Medina and Lisberger 2008;Popa et al 2013;Witter et al 2013). However, a poorly understood aspect of this activity is how it arises during development.…”
mentioning
confidence: 99%