Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus

Andersson, Gustav; Oscarsson, O.

doi:10.1007/bf00239553

Cited by 164 publications

(132 citation statements)

References 17 publications

Supporting

Mentioning

122

Contrasting

Order By: Relevance

“…5 A, B). Sensory-evoked calcium transients were exclusively observed at a particular cluster of dendrites corresponding to classical zones/microzones (Andersson and Oscarsson, 1978;Fig. 5C).…”

Section: Sensory-evoked Responses and Microzones At Aldolase C Comparmentioning

confidence: 95%

“…Synchronous complex spike activities are thought to arise from anatomical organization of olivo-cerebellar climbing fibers Voogd et al, 2003) and electrical coupling between neurons in the inferior olive (Blenkinsop and Lang, 2006). Recent imaging studies with high spatial resolution have revealed spatially fine parasagittal structures with high complex spike synchrony (Mukamel et al, 2009;Ozden et al, 2009;Schultz et al, 2009;Ghosh et al, 2011) that correspond to microzones defined with classical electrophysiological techniques (Bell and Kawasaki, 1972;Andersson and Oscarsson, 1978). These imaging studies have shown that microzones are activated spontaneously or by sensorimotor inputs, indicating that microzones represent functional units in the cerebellar cortex.…”

Section: Introductionmentioning

confidence: 99%

“…This synchronous structure is thought to correspond to a cerebellar "microzone," originally defined based on differential patterns of sensory responses (Andersson and Oscarsson, 1978). Synchronous complex spike activities are thought to arise from anatomical organization of olivo-cerebellar climbing fibers Voogd et al, 2003) and electrical coupling between neurons in the inferior olive (Blenkinsop and Lang, 2006).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Structure–Function Relationships between Aldolase C/Zebrin II Expression and Complex Spike Synchrony in the Cerebellum

et al. 2015

View full text Add to dashboard Cite

Simple and regular anatomical structure is a hallmark of the cerebellar cortex. Parasagittally arrayed alternate expression of aldolase C/zebrin II in Purkinje cells (PCs) has been extensively studied, but surprisingly little is known about its functional significance. Here we found a precise structure-function relationship between aldolase C expression and synchrony of PC complex spike activities that reflect climbing fiber inputs to PCs. We performed two-photon calcium imaging in transgenic mice in which aldolase C compartments can be visualized in vivo, and identified highly synchronous complex spike activities among aldolase C-positive or aldolase C-negative PCs, but not across these populations. The boundary of aldolase C compartments corresponded to that of complex spike synchrony at single-cell resolution. Sensory stimulation evoked aldolase C compartment-specific complex spike responses and synchrony. This result further revealed the structure-function segregation. In awake animals, complex spike synchrony both within and between PC populations across the aldolase C boundary were enhanced in response to sensory stimuli, in a way that two functionally distinct PC ensembles are coactivated. These results suggest that PC populations characterized by aldolase C expression precisely represent distinct functional units of the cerebellar cortex, and these functional units can cooperate to process sensory information in awake animals.

show abstract

Section: Sensory-evoked Responses and Microzones At Aldolase C Comparmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structure–Function Relationships between Aldolase C/Zebrin II Expression and Complex Spike Synchrony in the Cerebellum

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The cerebellar cortex shows both transverse organization based on its lobulation and longitudinal organization in which three subdivisions, the vermis, pars intermedia, and hemisphere, were originally recognized (Brodal, 1981). The longitudinal organization has been further elaborated by the demonstration of zones A-D (Voogd, 1967;Groenewegen and Voogd, 1977; and even much narrower "microzones" (Andersson and Oscarsson, 1978), which are based on topographic corticonuclear Purkinje cell projection and olivocortical climbing fiber projection. Recent analyses have shown that the axon of an inferior olivary neuron provides multiple climbing fibers to a single narrow longitudinal band-shaped area comparable in size to a cortical microzone and sends collaterals to a small area in the cerebellar nucleus (Sugihara et al, , 2001.…”

Section: Introductionmentioning

confidence: 99%

Molecular, Topographic, and Functional Organization of the Cerebellar Cortex: A Study with Combined Aldolase C and Olivocerebellar Labeling

Sugihara¹,

Shinoda²

2004

J. Neurosci.

278

453

View full text Add to dashboard Cite

Aldolase C (zebrin) expression in Purkinje cells reveals stripe-shaped compartments in the cerebellar cortex. However, it is not clear how these compartments are related to cerebellar functional localization. Therefore, we identified olivocerebellar projections to aldolase C compartments by labeling climbing fibers with biotinylated dextran injected into various small areas within the inferior olive in rats. Specific rostral and caudal aldolase C compartments were linked in an orderly manner by common olivocerebellar projection across the rostrocaudal boundary on lobule VIc-crus Ib. Based on the localization of the olivary origins of projection to similar compartments, the compartments and olivocerebellar projections could be sorted into five groups: group I, positive compartments extending from the posterior lobe to the anterior lobe innervated by the principal olive and some neighboring areas; group II, positive compartments localized within the posterior lobe innervated by several medial subnuclei; group III, vermal and central negative compartments innervated by the centrocaudal medial accessory olive; group IV, negative and lightly positive compartments in the hemisphere and the rostral and caudal pars intermedia innervated by the dorsal accessory olive and some neighboring areas; group V, the flocculus and nodulus. The olivocerebellar topography within each group was simple and suggests an "orientation axis" within the concerned parts of the inferior olive. Furthermore, parts of the inferior olive in each group receive specific afferent inputs, indicating a close relationship between aldolase C compartments and functional localization. Thus, the five-group scheme we propose here may integrate the molecular, topographic, and functional organization of the cerebellum.

show abstract

“…The intrinsic circuitry of the cerebellar cortex is well characterized, and its fundamental organization into parasagittal divisions has been revealed in great detail (Andersson and Oscarsson, 1978;Voogd and Glickstein, 1998;Shinoda, 2004, 2007;Voogd and Ruigrok, 2004). Specific olivo-cortico-nuclear connections form sets of functionally distinct compartments that, at the cortical level, are seen as "zones" with specific electrophysiological and cytochemical identities.…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Localization of Eyeblink-Related Microzones in Rabbit Cerebellar Cortex

Mostofi¹,

Holtzman²,

Grout³

et al. 2010

Journal of Neuroscience

103

116

View full text Add to dashboard Cite

The classically conditioned eyeblink response in the rabbit is one of the best-characterized behavioral models of associative learning. It is cerebellum dependent, with many studies indicating that the hemispheral part of Larsell's cerebellar cortical lobule VI (HVI) is critical for the acquisition and performance of learned responses. However, there remain uncertainties about the distribution of the critical regions within and around HVI. In this learning, the unconditional stimulus is thought to be carried by periocular-activated climbing fibers. Here, we have used a microelectrode array to perform systematic, high-resolution, electrophysiological mapping of lobule HVI and surrounding folia in rabbits, to identify regions with periocular-evoked climbing fiber activity. Climbing fiber local field potentials and single-unit action potentials were recorded, and electrode locations were reconstructed from histological examination of brain sections. Much of the sampled cerebellar cortex, including large parts of lobule HVI, was unresponsive to periocular input. However, short-latency ipsilateral periocular-evoked climbing fiber responses were reliably found within a region in the ventral part of the medial wall of lobule HVI, extending to the base of the primary fissure. Small infusions of the AMPA/kainate receptor antagonist CNQX into this electrophysiologically defined region in awake rabbits diminished or abolished conditioned responses. The known parasagittal zonation of the cerebellum, supported by zebrin immunohistochemistry, indicates that these areas have connections consistent with an essential role in eyeblink conditioning. These small eyeblink-related areas provide cerebellar cortical targets for analysis of eyeblink conditioning at a neuronal level but need to be localized with electrophysiological identification in individual animals.

show abstract

Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus

Cited by 164 publications

References 17 publications

Structure–Function Relationships between Aldolase C/Zebrin II Expression and Complex Spike Synchrony in the Cerebellum

Structure–Function Relationships between Aldolase C/Zebrin II Expression and Complex Spike Synchrony in the Cerebellum

Molecular, Topographic, and Functional Organization of the Cerebellar Cortex: A Study with Combined Aldolase C and Olivocerebellar Labeling

Electrophysiological Localization of Eyeblink-Related Microzones in Rabbit Cerebellar Cortex

Contact Info

Product

Resources

About