Clindamycin

LeFrock, Jack L.; Molavi, Abdolghader; Prince, Randall A.

doi:10.1016/s0025-7125(16)31445-6

Cited by 29 publications

(4 citation statements)

References 154 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clindamycin is one of the most common antimicrobial agents used in the treatment of anaerobic infections and continues to be highly effective in most situations (4,12). In obstetric and gynecologic practice, clindamycin plus an aminoglycoside is a frequent treatment regimen for pelvic soft tissue infections and in studies of safety and efficacy of new antimicrobials is often used as the standard treatment with which newer treatment regimens are compared (2,7,22).…”

mentioning

confidence: 99%

Occurrence of clindamycin-resistant anaerobic bacteria isolated from cultures taken following clindamycin therapy

Ohm‐Smith¹,

Sweet²,

Hadley³

1986

Antimicrob Agents Chemother

View full text Add to dashboard Cite

MICs of clindamycin were determined by the agar dilution method against anaerobic organisms isolated from endometrial cultures in women with pelvic soft tissue infections. Cultures were obtained from 100 women both before and after clindamycin therapy, from 107 women before therapy with clindamycin or another antimicrobial agent or after treatment with an antimicrobial agent other than clindamycin, and from 9 women 1 to 9 weeks after they were discharged from the hospital following clindamycin therapy. Only 5 (0.7%) of 685 isolates tested from women who had not received cfindamycin therapy were resistant to clindamycin. From the 100 cultures taken immediately after clindamycin therapy, 57 anaerobic bacteria were isolated from 28 cultures. Of the 40 anaerobic organisms for which MICs of clindamycin were determined, 25 (62.51%) were resistant to clindamycin (MIC 2 8 ,ug/ml). The most common organisms isolated after therapy were the anaerobic gram-positive cocci (of which 32 isolates were discovered); of 28 coccal isolates tested, 64% were clindamycin resistant. Four of seven (57%) of the Bacteroides isolates tested, one unidentified gram-positive nonsporing rod, one unidentified gram-negative coccus, and one Mobiluncus sp. were also clindamycin resistant. Of 18 anaerobic isolates from the nine cultures taken 1 to 9 weeks after hospital discharge, 55% were resistant to clindamycin. The clinical significance of these findings is unknown since all patients recovered without incident and remained well. However, the data suggest that physicians need to be aware that patients with recent exposure to clindamnycin may have clindamycin-resistant anaerobic organisms in a current infection. This may prevent the infection from responding to clindamycin treatment.Clindamycin is one of the most common antimicrobial agents used in the treatment of anaerobic infections and continues to be highly effective in most situations (4, 12). In obstetric and gynecologic practice, clindamycin plus an aminoglycoside is a frequent treatment regimen for pelvic soft tissue infections and in studies of safety and efficacy of new antimicrobials is often used as the standard treatment with which newer treatment regimens are compared (2,7,22). In the studies we have done, we have noticed that whereas the clinical outcomes from the clindamycin regimen have been acceptable, a number of clindamycin-resistant anaerobic bacteria, especially anaerobic gram-positive cocci, were isolated from posttreatment cultures. Whereas some investigators have noted the occurrence of clindamycin-resistant anaerobic bacteria in in vitro studies (3,9,14,18, 21), they have not specified the relationship of this occurrence to clindamycin treatment. Others who have presented results of studies in which clindamycin was used to treat obstetric or gynecologic infections have not reported results of posttreatment cultures or the susceptibilities of organisms from these cultures (2, 6, 23). The purpose of the present study was to review pre-and posttreatment culture results, or...

show abstract

mentioning

confidence: 99%

Occurrence of clindamycin-resistant anaerobic bacteria isolated from cultures taken following clindamycin therapy

Ohm‐Smith¹,

Sweet²,

Hadley³

1986

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that the concentration of clindamycin in these tissues is approximately 40-50% of the concentration in serum. 18 In a study, the concentration of clindamycin in bone and other tissue was above the minimal concentration at which 90% of the isolates are inhibited (MIC90) for pathogens that are likely to be introduced into the tissues in patients undergoing oral and maxillofacial surgery. 19 Clindamycin therapy is an effective means of treating periodontal disease due to obligate anaerobic bacilli, such as P. gingivalis and P. intermedia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Efficacy of Injectable-guided Tissue Regeneration with and without Clindamycin on the Colonization of Porphyromonas gingivalis by Real-time Polymerase Chain Reaction

Deepak

Josephin

Babu

et al. 2020

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

Aim: Aim of the present study was to evaluate the loading of clindamycin with injectable-guided tissue regeneration (GTR) will prevent the colonization of Porphyromonas gingivalis and to compare and assess the quantitative changes in P. gingivalis colony forming units (CFUs) by real-time polymerase chain reaction (PCR) analysis. Materials and methods: Thirty microbiological samples were pooled from the deepest periodontal pockets from the thirty sites from the two groups: group I-injectable GTR placed in the defect filled with demineralized freeze-dried bone allograft (DFDBA) and group II-clindamycin loaded injectable GTR placed in the defect filled with DFDBA. The total number of P. gingivalis CFUs was estimated using real-time PCR at baseline and 4 weeks after therapy. Results: A significant reduction in P. gingivalis CFUs at the end of 4 weeks was seen in both groups. Comparative evaluations between both groups at 4 weeks were with a mean of 4.44 ± 2.28 and 4.75 ± 3.32, respectively. Though there was a significant reduction in group II, the difference was statistically insignificant. Conclusion: The results suggest that clindamycin is beneficial in reducing microbial infection and can potentiate regeneration through host modulation. Clinical significance: Injectable GTR has the ability to mold according to the defect size and shape and eliminates the need to manipulate the membrane as required for the conventional membrane.

show abstract

“…Clindamycin reaches high concentrations in saliva, gingival crevicular fluid, and bone. Studies have shown that the concentration of clindamycin in these tissues is approximately 40% to 50% of the concentration in serum [14]. The high intracellular concentration of clindamycin and extended activity inside the bacterium yield a post-antibiotic effect by which the antimicrobial remains active although serum concentration levels are subinhibitory [15].…”

Section: Discussionmentioning

confidence: 99%

A Randomized Control Trial for conservative management of parotid abscess in children

et al. 2018

View full text Add to dashboard Cite

Background: The optimal conservative treatment protocol of parotid abscess in children is evaluated.Material and Methods: This is a randomized, prospective, cross-sectional study conducted between November 2013 and June 2017 in Nobel Medical College and Teaching Hospital. Thirty children (below 14 years age) suffering from parotid abscess diagnosed by ultrasonography were included in this study. Recurrent parotid abscess cases were excluded. The children were divided into 2 groups by computer assisted randomization into15 patients each. Group A were treated with intravenous Clindamycin while group B were given intravenous Ampicilin + Cloxacillin combination. Results: Five patients of group B did not respond to treatment and were then put on intravenous Clindamycin. Three of these patients responded to treatment but 2 developed multi-lobulated fluctuation and required incision + drainage. Remaining 10 patients in group B and all patients in Group A responded to medical treatment without recurrence. Five patients in group B developed severe diarrhea during antibiotic treatment but none of the patients in group A had this complaint. No patient developed any complications like parapharyngeal abscess or septicemia. Conclusion: Parotid abscess in children can be managed conservatively with intravenous Clindamycin without the need for incision and drainage. Journal of Nobel Medical College Volume 7, Number 1, Issue 12, January-June 2018, Page: 56-59

show abstract

Clindamycin

Cited by 29 publications

References 154 publications

Occurrence of clindamycin-resistant anaerobic bacteria isolated from cultures taken following clindamycin therapy

Occurrence of clindamycin-resistant anaerobic bacteria isolated from cultures taken following clindamycin therapy

Evaluation of Efficacy of Injectable-guided Tissue Regeneration with and without Clindamycin on the Colonization of Porphyromonas gingivalis by Real-time Polymerase Chain Reaction

A Randomized Control Trial for conservative management of parotid abscess in children

Contact Info

Product

Resources

About