Clindamycin alone may be enough. Is it time to abandon rifampicin for hidradenitis suppurativa?

Caposiena, Raffaele Dante; Bianchi, Luca

doi:10.1111/bjd.17597

Cited by 4 publications

(3 citation statements)

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“…At a 1-year follow-up, efficacy was maintained in 7 (41%) patients, while 10 (59%) relapsed after a mean time of 4.2 months. The data suggest that oral clindamycin with oral rifampicin for 12 weeks is an effective and tolerable regimen for HS [ 31 , 32 , 33 ].…”

Section: Current Antibiotic Therapy Of Hsmentioning

confidence: 99%

“…Moreover, greater efficacy of clindamycin alone on fistulas was demonstrated. It has been hypothesized that the lower concentration of clindamycin resulting from the inhibitory effect of rifampicin may reduce the efficacy of the treatment in severe HS lesions such as fistulas, which are often colonized by a polymorphous and abundant anaerobic flora [ 32 ].…”

Section: Current Antibiotic Therapy Of Hsmentioning

confidence: 99%

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Systemic Antibiotic Therapy in Hidradenitis Suppurativa: A Review on Treatment Landscape and Current Issues

et al. 2023

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Hidradenitis suppurativa (HS) is a chronic, recurrent, and inflammatory skin disease characterized by painful, deep-seated, nodules, abscesses, and sinus tracts in sensitive areas of the body, including axillary, inguinal, and anogenital regions. Antibiotics represent the first-line pharmacological treatment of HS because of their anti-inflammatory properties and antimicrobial effects. This narrative review summarizes the most significant current issues on the role of systemic antibiotics in the management of HS, critically analyzing the main limits of their use (antibiotic resistance and toxicity). Although, in the last decades, several cytokines have been implicated in the pathomechanism of HS and the research on the use of novel biologic agents in HS has been intensified, antibiotics remain a valid therapeutic approach. Future challenges regarding antibiotic therapy in HS comprise their use in association with biologics in the management of acute flare or as a bridge therapy to surgery.

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Section: Current Antibiotic Therapy Of Hsmentioning

confidence: 99%

Section: Current Antibiotic Therapy Of Hsmentioning

confidence: 99%

Systemic Antibiotic Therapy in Hidradenitis Suppurativa: A Review on Treatment Landscape and Current Issues

et al. 2023

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“…D ear E ditor , We thank Caposiena Caro and Bianchi for their response to our letter . Their very recent study adds another twist to the discussion of hidradenitis suppurativa (HS) treatment with antibiotics .…”

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confidence: 91%