Clindamycin-Loaded Nanosized Calcium Phosphates Powders as a Carrier of Active Substances

Słota, Dagmara; Piętak, Karina; Florkiewicz, Wioletta; Jampílek, Josef; Tomala, A.; Urbaniak, Mateusz M.; Tomaszewska, Agata; Rudnicka, Karolina; Sobczak-Kupiec, Agnieszka

doi:10.3390/nano13091469

Cited by 10 publications

(6 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The product was then dried in a laboratory dryer for 4 h at 104 °C. This method of synthesizing brushite was described in a previous article [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

Hybrid Polymer–Inorganic Materials with Hyaluronic Acid as Controlled Antibiotic Release Systems

Lis,

Szechyńska,

Träger

et al. 2023

Materials

Self Cite

View full text Add to dashboard Cite

In recent years, significant developments have taken place in scientific fields such as tissue and materials engineering, which allow for the development of new, intelligent biomaterials. An example of such biomaterials is drug delivery systems that release the active substance directly at the site where the therapeutic effect is required. In this research, polymeric materials and ceramic–polymer composites were developed as carriers for the antibiotic clindamycin. The preparation and characterization of biomaterials based on hyaluronic acid, collagen, and nano brushite obtained using the photocrosslinking technique under UV (ultraviolet) light are described. Physical and chemical analyses of the materials obtained were carried out using Fourier transform infrared spectroscopy (FT-IR) and optical microscopy. The sorption capacities were determined and subjected to in vitro incubation in simulated biological environments such as Ringer’s solution, simulated body fluid (SBF), phosphate-buffered saline (PBS), and distilled water. The antibiotic release rate was also measured. The study confirmed higher swelling capacity for materials with no addition of a ceramic phase, thus it can be concluded that brushite inhibits the penetration of the liquid medium into the interior of the samples, leading to faster absorption of the liquid medium. In addition, incubation tests confirmed preliminary biocompatibility. No drastic changes in pH values were observed, which suggests that the materials are stable under these conditions. The release rate of the antibiotic from the biomaterial into the incubation medium was determined using high-pressure liquid chromatography (HPLC). The concentration of the antibiotic in the incubation fluid increased steadily following a 14-day incubation in PBS, indicating continuous antibiotic release. Based on the results, it can be concluded that the developed polymeric material demonstrates potential for use as a carrier for the active substance.

show abstract

“…The product was then dried in a laboratory dryer for 4 h at 104 °C. This method of synthesizing brushite was described in a previous article [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

Hybrid Polymer–Inorganic Materials with Hyaluronic Acid as Controlled Antibiotic Release Systems

Lis,

Szechyńska,

Träger

et al. 2023

Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…In another paper, TCP, HAp, and DCPD were also compared and subjected to CLD modification by a physical sorption process. It was demonstrated that they have a similar potential to be used as DDSs, and that the rate of drug release is affected not only by the porosity, but also by the degree of crystallinity [71]. In each case, the physical sorption process was sufficient to observe CLD release for a minimum of seven days.…”

Section: Ceramic Carriers Of Clindamycinmentioning

confidence: 99%

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Słota,

Jampilek,

Sobczak-Kupiec

2024

IJMS

Self Cite

View full text Add to dashboard Cite

Targeted therapy represents a real opportunity to improve the health and lives of patients. Developments in this field are confirmed by the fact that the global market for drug carriers was worth nearly $40 million in 2022. For this reason, materials engineering and the development of new drug carrier compositions for targeted therapy has become a key area of research in pharmaceutical drug delivery in recent years. Ceramics, polymers, and metals, as well as composites, are of great interest, as when they are appropriately processed or combined with each other, it is possible to obtain biomaterials for hard tissues, soft tissues, and skin applications. After appropriate modification, these materials can release the drug directly at the site requiring a therapeutic effect. This brief literature review characterizes routes of drug delivery into the body and discusses biomaterials from different groups, options for their modification with clindamycin, an antibiotic used for infections caused by aerobic and anaerobic Gram-positive bacteria, and different methods for the final processing of carriers. Examples of coating materials for skin wound healing, acne therapy, and bone tissue fillers are given. Furthermore, the reasons why the use of antibiotic therapy is crucial for a smooth and successful recovery and the risks of bacterial infections are explained. It was demonstrated that there is no single proven delivery scheme, and that the drug can be successfully released from different carriers depending on the destination.

show abstract

“…Bioactive calcium phosphate ceramics (CaPs) are a recently discovered novel inorganic material with a porous structure that can be modified with active substances to be used as drug carriers to control the release of active substances. Dagmara Słota et al [41] modified CaPs with more clindamycin loading by physisorption. Drug adsorption on ceramic powders is mainly accomplished by forming bonds between Ca 2+ ions on the ceramic surface and oxygen atoms in the drug molecule.…”

Section: Porous Types Of Nanomaterialsmentioning

confidence: 99%

Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

Wang,

Chen,

Huang

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a common malignant tumor, and traditional treatments include surgical resection and radiotherapy. However, local recurrence, distal metastasis, and intestinal obstruction are significant problems. Oral nano-formulation is a promising treatment strategy for CRC. This study introduces physiological and environmental factors, the main challenges of CRC treatment, and the need for a novel oral colon-targeted drug delivery system (OCDDS). This study reviews the research progress of controlled-release, responsive, magnetic, targeted, and other oral nano-formulations in the direction of CRC treatment, in addition to the advantages of oral colon-targeted nano-formulations and concerns about the oral delivery of related therapeutic agents to inspire related research.

show abstract

Clindamycin-Loaded Nanosized Calcium Phosphates Powders as a Carrier of Active Substances

Cited by 10 publications

References 63 publications

Hybrid Polymer–Inorganic Materials with Hyaluronic Acid as Controlled Antibiotic Release Systems

Hybrid Polymer–Inorganic Materials with Hyaluronic Acid as Controlled Antibiotic Release Systems

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

Contact Info

Product

Resources

About