Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: A randomized control trial

Abstract

Our data suggested that the efficacy of CS lotion was significantly more than C lotion with respect to the TLC and ASI, although there was no significant difference between CS and CT lotion.

Optimizing Non-Antibiotic Treatments for Patients with Acne: A Review

“…BPO benzoyl peroxide. Clindamycin 1% + BPO 3% gel: Schaller et al [20], Eichenfield et al [21]; clindamycin 1% + BPO 5% gel BID: Langner et al [30], Jackson et al [38]; clindamycin 1% + tretinoin 0.025% lotion: Jackson et al [38], NilFroushzadeh et al [39]; clindamycin 1% + BPO 5% gel: Langner et al [30]; clindamycin 1% lotion + adapalene 0.1% gel: Wolf et al [40]. BPO 3% gel: Eichenfield et al [28]; BPO 2.5% gel: Gollnick et al [22], Babaeinejad and Fouladi [29].…”

“…Both clindamycin 1% nanoemulsion gel and conventional clindamycin gel were highly efficacious at decreasing TLC (69.3% vs. 51.9%, respectively), while clindamycin lotion only produced a modest improvement (28.6%) [39–41]. Clindamycin’s efficacy was enhanced with the addition of salicylic acid: clindamycin 1% combined with 2% salicylic acid lotion resulted in a TLC reduction of 77.9% [39]. Topical clindamycin was very well tolerated, with side effects including mild burning, stinging and scaling.…”