Clindamycin phosphate scavenges hydroxyl radical

Sato, Emiko; Kato, Minori; Kohno, Masahiro; Niwano, Yoshimi

doi:10.1111/j.1365-4632.2007.03338.x

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…In addition, some drugs used in acne treatment, such as tetracycline and macrolide, show the ability to suppress an inflammatory reaction mediated by ROS in addition to their antibacterial activity 3,32. Furthermore, clindamycin scavenges hydroxyl radical, whereas it does not scavenge superoxide anion radical 33. In the present study, zinc ascorbate was found to have SOD-like activity, and it is possible that this compound can suppress ROS production.…”

Section: Discussionmentioning

confidence: 46%

Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli

Iinuma¹,

Tsuboi²

2012

CCID

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Background:Acne vulgaris is a common dermatological disease, and its pathogenesis is multifactorial.Objective:We examined whether the ascorbic acid derivative zinc ascorbate has superoxide dismutase (SOD)-like activity. SOD is an enzyme that controls reactive oxygen species production. In addition, the in vitro antimicrobial activity of zinc ascorbate against the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli was tested either alone or in combination with a variety of antimicrobial agents; their fractional inhibitory concentration index was determined using checkerboard tests.Methods:The SOD-like activity was measured in comparison with other ascorbic acid derivatives (ascorbic acid, magnesium ascorbyl phosphate, and sodium ascorbyl phosphate) and zinc. The antimicrobial susceptibility of twelve strains each of S. aureus and E. coli isolated from patients with dermatological infections was tested, in comparison to a type strain of S. aureus and E. coli.Results:Zinc ascorbate had significant (P < 0.001) SOD-like activity compared with other ascorbic acid derivatives and zinc. Moreover, it showed antimicrobial activity against a type strain of S. aureus and E. coli, and its concentration (0.064% and 0.128% for S. aureus and E. coli, respectively) was sufficiently lower than the normal dose (5%) of other ascorbic acid derivatives. Furthermore, combinations of zinc ascorbate with clindamycin, erythromycin, and imipenem against S. aureus (average fractional inhibitory concentration, 0.59–0.90), and with imipenem against E. coli (average fractional inhibitory concentration, 0.64) isolated from patients with dermatological infections showed an additive effect.Conclusions:Our results provide novel evidence that zinc ascorbate may be effective for acne treatment.

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Section: Discussionmentioning

confidence: 46%

Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli

Iinuma¹,

Tsuboi²

2012

CCID

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“…This may be also due to the fact that phosphate was believed to be a hydroxyl radical scavenger [27], indicating a more negative anion effect occurred in the case of this PO 4 3− species rather than that demonstrated with Cl − . Fig.…”

Section: Effect Of Anionsmentioning

confidence: 95%

Efficient decolorization of azo dye Reactive Black B involving aromatic fragment degradation in buffered Co2+/PMS oxidative processes with a ppb level dosage of Co2+-catalyst

Huang

et al. 2009

Journal of Hazardous Materials

304

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“…Similarly, other studies have quantitatively analyzed the rate of HO • generation from water exposed to ultrasonic irradiation [33–35]. …”

Section: Application Of Esr To Measure Oxygen Free Radicalsmentioning

confidence: 99%

“…In fact, we recently proposed HOOOH to be one such candidate molecule, as summarized in Fig. 7 [35]. …”

Section: Evaluation Of Oxidative Stress By Esrmentioning

confidence: 99%

Applications of Electron Spin Resonance Spectrometry for Reactive Oxygen Species and Reactive Nitrogen Species Research

Kohno

2010

J. Clin. Biochem. Nutr.

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Electron spin resonance (ESR) spectroscopy has been widely applied in the research of biological free radicals for quantitative and qualitative analyses of reactive oxygen species (ROS) and reactive nitrogen species (RNS). The ESR spin-trapping method was developed in the early 1970s and enabled the analysis of short-lived free radicals. This method is now widely used as one of the most powerful tools for free radical studies. In this report, some of the studies that applied ESR for the measurement of ROS and RNS during oxidative stress are discussed.

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Clindamycin phosphate scavenges hydroxyl radical

Abstract: This is the first report of the direct scavenging effect of CLDMP on hydroxyl radical, and the effect may improve the inflammatory response caused by invading bacteria.

Cited by 7 publications

References 23 publications

Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli

Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli

Efficient decolorization of azo dye Reactive Black B involving aromatic fragment degradation in buffered Co2+/PMS oxidative processes with a ppb level dosage of Co2+-catalyst

Applications of Electron Spin Resonance Spectrometry for Reactive Oxygen Species and Reactive Nitrogen Species Research

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