Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases

Yavuz, Göknur Özaydın; Yavuz, İbrahim Halil; Bayram, İrfan; Aktar, Rojda; Bilgili, Serap Güneş

doi:10.5114/ada.2018.77726

Cited by 8 publications

(5 citation statements)

References 16 publications

(26 reference statements)

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“…UVB wavelength can significantly induce skin inflammation in patients with SLE 7–9 . Chronic UV exposure is also an important risk factor for DLE 10 . However, the mechanisms through which SLE and DLE skin is predisposed to persistent inflammation following UVB exposure are unclear.…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet light induces HERV expression to activate RIG‐I signalling pathway in keratinocytes

Min

Zheng

et al. 2022

Experimental Dermatology

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Skin inflammation and photosensitivity are common in lupus erythematosus (LE) patients, and ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) patients. Type I interferons (IFN) are upregulated in LE skin after UV exposure; however, the mechanisms to explain UVB‐induced inflammation remain unclear. Here, we demonstrated that UVB irradiation‐induced activation of human endogenous retroviruses (HERVs) plays a major role in the immune response. UVB‐induced HERV‐associated dsRNA transcription and subsequent activation of the innate antiviral RIG‐I/MDA5/IRF7 pathway led to downstream transcription of interferon‐stimulated genes, which promotes UVB‐induced apoptosis and proliferation inhibition in keratinocytes through RIG‐I and MDA5 pathways. Our findings indicate that UVB irradiation induces HERV‐dsRNA overexpression, and the dsRNA‐sensing innate immunity pathway promotes type I IFN production, which may be a potential mechanism of skin inflammatory response and skin lesion of SLE/DLE.

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Section: Introductionmentioning

confidence: 99%

Ultraviolet light induces HERV expression to activate RIG‐I signalling pathway in keratinocytes

Min

Zheng

et al. 2022

Experimental Dermatology

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“…Another study found ANA positivity in only 23.7% of patients. 26 This study examined various predictors that resulted in adverse pregnancy outcomes. A significant association was found between HTN and miscarriage, preterm birth, pre-eclampsia and LN.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes in Systemic Lupus Erythematosus Women

Al-Riyami

Salman

Al-Rashdi

et al. 2021

Sultan Qaboos Univ Med J

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Objectives: This study was conducted to assess pregnancy outcomes in women with systemic lupus erythematosus (SLE) in Oman. Methods: A retrospective cohort study of 149 pregnancies in 98 women with SLE was conducted over 10 years to evaluate the impact of clinical and laboratory parameters in predicting adverse pregnancy outcomes. Results: Mean maternal age was 30.6 ± 5 years ranging from 20–44 years, and the mean disease duration was 10 ± 5 years, ranging from 2–27 years. The most common maternal manifestations were joint pain in 36 (24.2%), lupus nephritis (LN) in 18 (12.08%), preeclampsia in 11 (7.4%), eclampsia in three (2%) and lupus flare in one pregnancy. The live birth rate was 139 (93.3%) with a mean gestational age of 36 ± 2 weeks ranging from 26–40 weeks. In total, 55 (39.6%) were preterm deliveries, six (4%) pregnancies ended in miscarriage, and four (2.7%) resulted in intrauterine fetal death. Intrauterine growth restriction was observed in 49 babies (35%). A significant association was found between hypertension (HTN) and miscarriage (P = 0.024) and preterm birth (P = 0.019). In addition, HTN was positively associated with preeclampsia (P = 0.004) and LN (P = 0.048). Antiphospholipid syndrome impacted preterm birth (P = 0.013) and postpartem haemorrhage (PPH) (P = 0.027) and was found to be a significant predictor for women developing deep vein thrombosis and pulmonary embolism (P <0.001 for both). Conclusion: Despite potential complications, most pregnancies complicated by SLE in Oman result in good outcomes. Adverse pregnancy outcomes, however, may still occur in women with SLE. In women with SLE, pregnancy planning, careful antenatal monitoring and efficient SLE treatment need to be undertaken for successful pregnancy outcomes. Keywords: Systemic Lupus Erythematosus; Pregnancy Outcomes; Lupus Nephritis; Antiphospholipid Antibodies; Neonatal Lupus.

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“…There were previous reports investigating rates of positive family history for discoid lupus erythematosus (DLE) in DLE patient cohorts. However, the rate varied significantly among different studies, ranging from 0% to 20% 2–5. The differences in rates were likely due to the populations studied and differences in whether family histories included first-degree relatives and/or more distant relatives.…”

Section: Introductionmentioning

confidence: 93%

“…However, the rate varied significantly among different studies, ranging from 0% to 20%. [2][3][4][5] The differences in rates were likely due to the populations studied and differences in whether family histories included first-degree relatives and/or more distant relatives. Other limitations were small sample size, homogeneous racial or ethnic populations, and lack of inclusion of other subtypes of CLE.…”

Section: Introductionmentioning

confidence: 99%

Black patients with cutaneous lupus are associated with positive family history of cutaneous lupus and systemic lupus

Keum

Brown²,

Chong³

2022

Lupus Sci Med

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ObjectivesVarious genetic polymorphisms have been associated with an increased risk of cutaneous lupus erythematosus (CLE). However, it is not fully known how often positive family histories occur in patients with CLE. The aims of this study are to determine the rate of positive family history among patients with CLE and to identify risk factors associated with positive family history.MethodsA retrospective cohort study was conducted among 338 patients with CLE seen in outpatient dermatology clinics in a tertiary referral centre in Dallas, Texas. The primary outcome was positive family history of CLE and/or SLE, as defined by the presence of self-reported CLE and/or SLE in first-degree or more distant relatives of a patient. Univariate analyses were performed to identify risk factors associated with positive family history of CLE and/or SLE in patients with CLE. Multivariable logistic regression analyses were performed to determine significant predictors of positive family history of CLE and/or SLE.Results34% (n=114) of patients reported positive family history of CLE and/or SLE. 7% (n=23) of patients with CLE had relatives with CLE, with 5% (n=18) having a first-degree relative with CLE. 30% (n=102) of patients with CLE had relatives with SLE, and 15% (n=52) had a first-degree relative with SLE. Black patients were more likely to have positive family history of CLE and/or SLE (OR 2.13, 95% CI 1.23 to 3.69, p=0.007).ConclusionsMore patients with CLE had positive family history of SLE than CLE. Black patients with CLE were more likely to have a relative with CLE and/or SLE. Providers can use this information to counsel patients with CLE on the risk of other family members having CLE and/or SLE. These data may help identify potentially new genetic polymorphisms associated with positive family history.

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Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases

Cited by 8 publications

References 16 publications

Ultraviolet light induces HERV expression to activate RIG‐I signalling pathway in keratinocytes

Ultraviolet light induces HERV expression to activate RIG‐I signalling pathway in keratinocytes

Pregnancy Outcomes in Systemic Lupus Erythematosus Women

Black patients with cutaneous lupus are associated with positive family history of cutaneous lupus and systemic lupus

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