“…The large number and variability of early clinical manifestations of cortisol-secreting adenoma make it difficult to diagnose, which is reflected in the long duration of the disease, that is, the time from the onset of the first symptoms to the correct diagnosis [6]. Patients most frequently complain of fatigue/weakness (85%), changes in appearance (63%), emotional instability (61%), cognitive problems (49%), depression (32%), and sleep problems (12%); 80% report problems in family life and relationships with their partner, and 56% report problems at work [14].…”