Clinical analyses on salvage lymphadenectomy through cervical incision for patients with cervical and cervicothoracic recurrences after esophagectomy

Abstract

Background: Locoregional recurrences are often observed after esophagectomy with lymphadenectomy.The treatment strategy for these patients has not been established completely. The purpose of this study was to evaluate the prognosis of salvage lymphadenectomy through the cervical incision for cervical and cervicothoracic recurrences. Results: The median disease-free survival (DFS) was 8 months. The median PSL-OS was 40 months (95% CI: 8.850-71.150). The 1-, 2-, 3-and 5-year PSL-OS rate were 87%, 58%, 52% and 41%, respectively. Univariate and multivariate analyses confirmed the initial TNM stage was the only independent prognostic factor for PSL-OS (P=0.000 by log-rank test, P=0.009 by Cox hazards model, HR 3.999, 95% CI: 1.413-11.316) among these patients. Conclusions: PSL survival could be considerable for patients with early initial tumor stage. Prospective studies are warranted to clarify the value of salvage lymphadenectomy.

Efficacy and Prognosis of Chemoradiotherapy for 501 Patients With Postoperative Recurrence of Esophageal Cancer

“…Once the treatment failure occurs, most patients have a poor prognosis and die within 1 year [8,9]. At present, the main salvage treatment options for patients with postoperative recurrence include surgery, radiotherapy, chemotherapy, and chemoradiotherapy, while the curative effect is not ideal [10][11][12], and the optimal treatment regimen needs to be determined. Neoadjuvant radiotherapy and chemotherapy can improve the overall survival rate (OS) and local tumor control rate of patients, but neoadjuvant radiotherapy often increases the difficulties associated with surgery due to tissue edema and hemorrhage.…”