Clinical analysis of 26 patients with histologically proven placental chorioangiomas

Wu, Zaigui; Hu, Wensheng

doi:10.1016/j.ejogrb.2015.12.009

Cited by 29 publications

(38 citation statements)

References 30 publications

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“…The search identified 322 articles, of which 68 were assessed in full text with respect to their eligibility for inclusion (Table S1) and 28 studies were included in the systematic review (Table S2, Figure 2) [1][2][3][4]6,7,9,10,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] . These 28 studies included 161 singleton pregnancies (144 from cohort studies and 17 from case reports) affected by placental chorioangioma without associated structural anomalies.…”

Section: General Characteristicsmentioning

confidence: 99%

“…These 28 studies included 161 singleton pregnancies (144 from cohort studies and 17 from case reports) affected by placental chorioangioma without associated structural anomalies. Of these studies, 11 were cohort studies [1][2][3][4]6,7,[19][20][21][22][23] , while 17 were case reports of pregnancies undergoing in-utero treatment of the chorioangioma (Table S2) 9,10,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] .…”

Section: General Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta‐analysis

Buca

Iacovella

Khalil

et al. 2020

Ultrasound in Obstet & Gyne

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Objective To report the perinatal outcome of singleton pregnancies complicated by placental chorioangioma diagnosed on prenatal ultrasound. Methods MEDLINE, EMBASE, CINAHL and http://ClinicalTrials.gov databases were searched for studies reporting the outcome of pregnancies complicated by placental chorioangioma. Inclusion criteria were singleton pregnancy diagnosed with placental chorioangioma on prenatal ultrasound, with no other associated structural anomaly. The primary outcome was perinatal mortality. Secondary outcomes included associated non‐structural anomalies detected on prenatal ultrasound (including fetal hydrops, anemia, polyhydramnios, signs of hyperdynamic circulation and small‐for‐gestational‐age (SGA) fetus), SGA at birth, composite neonatal morbidity and preterm birth. Outcome was assessed separately in pregnancies undergoing and those not undergoing fetal therapy. Subanalyses were performed according to the presence of hydrops and the size of the tumor in all pregnancies diagnosed with chorioangioma. Random‐effects meta‐analyses of proportions were used to analyze the data. Results Twenty‐eight studies (161 pregnancies) were included. In pregnancies complicated by chorioangioma that did not undergo intervention, intrauterine death occurred in 8.2% (95% CI, 3.8–15.0%), while neonatal death and perinatal death occurred in 3.8% (95% CI, 1.0–8.1%) and 11.1% (95% CI, 5.0–19.4%), respectively. SGA at birth was present in 24.0% (95% CI, 13.5–36.5%) of cases, while preterm birth < 37 weeks complicated 34.1% (95% CI, 21.1–48.3%) of pregnancies. Composite neonatal morbidity occurred in 12.0% (95% CI, 4.5–22.3%) of cases. On ultrasound, signs of fetal hyperdynamic circulation were present in 21.0% (95% CI, 9.6–35.3%) of cases, while peak systolic velocity in the fetal middle cerebral artery was increased in 20.6% (95% CI, 10.9–32.3%). Subanalysis according to the size of chorioangioma, including both pregnancies that did and those that did not undergo intervention, showed a progressive increase in the occurrence of most of the outcomes explored with increasing size of the tumor. Furthermore, the prevalence of adverse perinatal outcome was high in pregnancies complicated by chorioangioma presenting with fetal hydrops. There was no randomized controlled trial comparing intervention vs expectant management in pregnancies complicated by chorioangioma with signs of fetal compromise (hydrops or hyperdynamic circulation). Overall, perinatal mortality occurred in 31.2% (95% CI, 18.1–46.1%) of fetuses undergoing in‐utero therapy, and 57.3% (95% CI, 39.2–74.4%) had resolution of hydrops or hyperdynamic circulation after treatment. Conclusions Placental chorioangioma is associated with adverse perinatal outcome. The size of the mass and presence of fetal hydrops are likely to be the main determinants of perinatal outcome in affected pregnancies. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.

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Section: General Characteristicsmentioning

confidence: 99%

Section: General Characteristicsmentioning

confidence: 99%

Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta‐analysis

Buca

Iacovella

Khalil

et al. 2020

Ultrasound in Obstet & Gyne

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“…However, most chorioangiomas are small and can be found in postpartum placental pathology examination without any complications ever presenting. 2,3 What was noteworthy in our case was that multiple non-giant chorioangiomas may cause fetal complications despite the difficulty of prenatal diagnosis. While colour Doppler echography is considered useful for diagnosing chorioangioma, prenatal diagnosis is sometimes difficult for small lesions.…”

Section: Discussionmentioning

confidence: 69%

Severe fetal cardiomegaly caused by multiple non-giant placental chorioangiomas

2019

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A pregnant woman was referred to our hospital due to fetal cardiomegaly. We recognised a dilated umbilical vein, which raised a suspicion of placental chorioangioma. A male neonate was delivered at 37 weeks of gestation. The cardiomegaly was gradually improved. Pathological examination identified five non-giant placental chorioangiomas. Multiple non-giant chorioangiomas may cause fetal complications despite the difficulty of prenatal diagnosis.

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“…As another example, placental chorioangiomas are benign vascular neoplasms that are detected microscopically by the presence of abnormally enlarged stem villi, degenerative areas of calcification, numerous capillaries, and surrounding trophoblasts . They are clinically associated with fetal complications, including growth restriction, polyhydramnios, high cardiac output failure, and even fetal demise.…”

Section: Methodsmentioning

confidence: 99%

Characterization of Placental Microvasculature Using Superb Microvascular Imaging

Mack

Mastrobattista

Gandhi

et al. 2019

J of Ultrasound Medicine

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uses clutter suppression to extract flow signals at rapid frame rates, which provides high-resolution vessel-branching details without the need for contrast agents. The potential diagnostic benefits of SMI, as described in other areas of medicine, requires further exploration during pregnancy. In this pictorial essay, we demonstrate the complementary use of SMI compared to conventional Doppler ultrasound and how it may improve our ability to characterize placental microvascular patterns without the need for ultrasound contrast agents.

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Clinical analysis of 26 patients with histologically proven placental chorioangiomas

Cited by 29 publications

References 30 publications

Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta‐analysis

Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta‐analysis

Severe fetal cardiomegaly caused by multiple non-giant placental chorioangiomas

Characterization of Placental Microvasculature Using Superb Microvascular Imaging

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