Clinical analysis of 52 adolescent patients with ovarian masses ≥10 cm in diameter

Zhang, Bo; Zhang, Lu; Meng, Guofeng

doi:10.1177/03000605211032781

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…The majority of the cases were between 16 and 20 years old (87.27%).Among the 55 ovarian masses, 14 (25.45%) were 10cm or more in size (Table 1), and among which 11 were benign, 3 were malignant. Like the studies of Zhang et al and Grigore et al, 7,8 we also found teratomas (5/14, 35.71%) constitute the most common type of large ovarian masses in adolescents.The ovarian mass in the perimenarchal and young adult population shows a spectrum of pathology from functional non-neoplastic cysts to benign to highly aggressive malignant tumours. Tumours of germ cell origin like teratoma and dysgerminoma are predominant during infancy and childhood.…”

Section: Resultssupporting

confidence: 86%

Clinicopathological Study of Ovarian Masses in Adolescent Girls and Young Women in a Tertiary Care Hospital

Kundu,

Bhattacharyya,

Nandy

et al. 2023

J Coll Med Sci-Nepal

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IntroductionOvarian masses include both neoplastic and non-neoplastic lesions. Fortunately, though most ovarian masses in adolescents are benign, about 10% turn out to be malignant. Thus, ovarian tumours constitute an important part of paediatric oncology and often create diagnostic dilemmas. The present study aimed to calculate the frequency and clinicopathological patterns of ovarian masses in adolescent and young females and briefly discuss and compare with the existing literature.MethodsThis was a retrospective study conducted at the Department of Pathology of a tertiary care hospital in West Bengal, India. All tissue samples of ovarian masses received in the Pathology department between 10 to 20 years of age group over 6 years (January 2016-December 2021) were included in this study. We evaluated the clinicopathological parameters of the cases. The statistical analysis was performed using Epi Info 7 software.ResultsA total of 53 cases were included in present study of the defined age group over 6 years (January 2016 – December 2021), of which 2 had bilateral lesions, so a total of 55 ovarian masses were studied. Of 55 ovarian masses, 50 (90.9%) were benign tumours or non-neoplastic lesions and 5 ovarian masses (9.1%) were malignant. Mature cystic teratoma was the most common type of tumour in this age group.ConclusionsOvarian masses in perimenarchal and young adults show diversity in the histological spectrum. Although most are benign, early diagnosis preserves fertility in this tender age group.

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Section: Resultssupporting

confidence: 86%

Clinicopathological Study of Ovarian Masses in Adolescent Girls and Young Women in a Tertiary Care Hospital

Kundu,

Bhattacharyya,

Nandy

et al. 2023

J Coll Med Sci-Nepal

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“…In our series, ovarian tumors in adolescents accounted for less than 5% of all ovarian tumors, and the majority of these cases were functional ovarian cysts. Reports from China found that 5% of all ovarian tumors in china occurred in children and adolescents [ 27 , 28 ]. Conversely, reports from Ghana and Nigeria showed a higher rate of ovarian tumors (8–9%) in children and adolescents [ 10 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Ovarian neoplasia in adolescence: a retrospective chart review of girls with neoplastic ovarian tumors in Saudi Arabia

Aldakhil

Aljuhaimi

AlKhattabi³

et al. 2022

J Ovarian Res

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Background Ovarian neoplasia in children and adolescents is a rare tumor. The diagnosis and management of such tumors is often difficult and delayed due to non-specific symptoms and low suspicion. Surgical management that preserves fertility and ovarian function should be the goal. Objective This study aimed to review the clinical presentation, tumor characteristics, and management of Saudi Arabian adolescents. Methods A retrospective chart review was conducted on adolescent girls aged 19 or less admitted to tow referral hospital in Riyadh, Saudi Arabia, diagnosed with adnexal mass over an 8 years’ period; patients who were older than 19 were excluded. The data collected from patients’ charts included age, presenting symptoms, radiologic findings, type of surgery, specialist who performed the surgery, and histopathology of the tumors. We classified patients according to age using the three WHO developmental stages: early adolescence (10–13 years old), middle adolescence (14–16 years old), and late adolescence (16–17 years old). The statistical study used SPSS version 18.0 to determine the data’s frequency, distributions, and means (SPSS Inc., Chicago, IL). Results We analyzed 164 patients, between 10 and 19 years old, admitted to two hospitals between 2009 and 2017. We found that 85% of these patients underwent surgery for adnexal mass removal, and 90.2% were symptomatic or emergency cases. The majority of our patients were post-menarche (96.95%), and were between the ages of 14 and 19. The most common surgical procedure for tumor removal was laparoscopic cystectomy (74.4%). An adnexal mass with a solid component on ultrasound is the most commonly found indicator of malignancy. The majority of tumors were benign (32.3%). Germ cell tumors were the most common (68.7%) malignant tumor, and yolk sac tumors were the most common subgroup of germ cell tumors. When managed by a gynecologist, surgical intervention can be a successful method of preserving fertility. Conclusions Our results confirm that the majority of neoplastic ovarian tumors in children and adolescents are benign, and surgical intervention can be used to maintain fertility, especially when managed by a gynecologist. This is one of the largest reported series and the first from our area.

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“…Mass diameters were significantly higher in the laparotomy group and the operative duration was significantly shorter in the laparoscopy group. 19 Ovarian tumors >9.9 cm are associated with an increased risk of malignant transformation, and tumors >15 cm are associated with more aggressive behavior. 20 Tumor rupture, dissemination and implantation may occur during the operation of malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis Difficulties and Minimally Invasive Treatment for Ovarian Masses in Adolescents

Ţarcă¹,

Trandafir²,

Cojocaru³

et al. 2022

IJWH

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About 1% of childhood tumors can be malignant ovarian tumors and differential diagnosis with benign ones is sometimes difficult before surgery. Concerning the management of such tumors in adolescents for which future fertility is a concern, there is specific interest in their malignant potential and the possible use of ovarian-sparing operative techniques, as well the suitability of chemotherapy. To exemplify the difficulties of preoperative differential diagnosis, personalized approach and the difficulties of deciding to preserve the affected ovary, we report a rare case of a 14-year-old female adolescent with a growing abdominal painless mass and without any other chronic diseases. After physical examination and imaging investigations, laparoscopic surgical procedure is performed, the peritoneal cavity is explored and the well-delimited gigantic tumor is removed. Considering the normally looking pelvis and absence of adenopathy, as well as the patient’s age and wish to have children, both ovaries are preserved. Laparoscopy has become the gold standard in the management of this condition, although there are few studies that report this approach in children; the differential diagnosis between a benign and a malignant tumor cannot be established exactly until after the histological examination, which revealed in our case a cystic teratoma with mature tissues. A better understanding of clinical features and evolution of giant ovarian masses in adolescents could help clinicians better diagnose and treat such lesions.

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Clinical analysis of 52 adolescent patients with ovarian masses ≥10 cm in diameter

Cited by 5 publications

References 32 publications

Clinicopathological Study of Ovarian Masses in Adolescent Girls and Young Women in a Tertiary Care Hospital

Clinicopathological Study of Ovarian Masses in Adolescent Girls and Young Women in a Tertiary Care Hospital

Ovarian neoplasia in adolescence: a retrospective chart review of girls with neoplastic ovarian tumors in Saudi Arabia

Diagnosis Difficulties and Minimally Invasive Treatment for Ovarian Masses in Adolescents

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