Clinical Analysis of Castleman’s Disease of the Lacrimal Gland

Abstract

Objective. To explore the clinical manifestations, imaging characteristics, and pathological characteristics of Castleman’s disease of the lacrimal gland, enhance the knowledge of the disease, and improve the level of its diagnosis and treatment. Methods. In the retrospective study, the data of 5 patients diagnosed with Castleman’s disease of the lacrimal gland in Tianjin Medical University Eye Hospital from 2014 to 2018 were analyzed, and the relevant literature was reviewed. Results. All the 5 patients were confirmed by pathological examination. Clinical manifestations were characterized by mass occupying lesions in the lacrimal gland area, without obvious pain, accompanied by eyelid swelling and ptosis, as well as space-occupying symptoms. Imaging examination showed that there was a soft tissue mass in the enlarged lacrimal gland area, and the mass was rich in blood flows while showing no obvious specificity, which could invade the surrounding muscles. All patients underwent surgical resection. Pathological results showed that 1 case was of the hyaline-vascular type, 3 cases were of the plasma cell type, and 1 case showed malignant transformation to plasma cell tumor. Conclusion. Castleman’s disease of the lacrimal gland is a rare orbital lymphoproliferative disease lacking specificity in clinical manifestations and imaging examination. As there are difficulties in differentiating the disease from orbital inflammatory pseudotumor and orbital lymphoma, its diagnosis still depends on pathological examination. The disease is mainly treated with surgical resection, and the pathological type is determined postoperatively.

A Rare Case of Orbital Castleman Disease with Overlapping IgG4-Related Disease

“…MCD is a systemic lymphoproliferative disorder that can lead to mass lesion formation in various parts of the body, including the lungs, kidneys, and extranodal sites. Although orbital tissue involvement is relatively rare due to the lack of lymphatic components, previous cases of MCD affecting the lacrimal gland have been reported [ 8 , 9 ]. Venizelos et al reported that orbital involvement might be the initial clinical presentation of CD and those with unicentric hyaline-vascular CD cases showed no association with systemic symptoms and were rarely recurrent [ 10 ].…”

Idiopathic Multicentric Castleman Disease with Cutaneous Manifestation: Case Report

“…Commonly affected areas include the mediastinum, the axillary and inguinal regions, as well as the abdominal cavity [8]. Case reports have also highlighted extranodal incidents of CD; namely, in the pancreas, the lacrimal glands, and intramuscularly [7,[11][12][13]. Constitutional symptoms in UCD are rare and, when present, give rise to suspicions of other clinical entities, rather than CD [4].…”