Clinical Analysis of Operative Results in Patient With Positive Hiv

Motojima, Ryuji; Enomoto, Kazuo; Yoshida, Masami; Iwasaki, Koutarou; Kobayashi, Osamu; Ochiai, Takenori

doi:10.3919/jjsa.66.1252

Cited by 3 publications

(1 citation statement)

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“…However, she underwent total gastrectomy without any complications after surgery because the CD4 lymphocyte level was elevated to 125/mm 3 . Furthermore, she underwent S-1 therapy while performing HAART and monitoring CD4 lymphocyte In Japan, 134 patients positive for HIV who had no serious complications after various operations with CD4 lymphocyte levels greater than 200/mm 3 have been reported [14]. Similarly, 9 patients with gastric cancer associated with positive HIV who had no serious complications after gastrectomy with CD4 lymphocyte levels greater than 200/mm 3 have been reported.…”

Section: Discussionmentioning

confidence: 94%

Gastrectomy and chemotherapy with S-1 for gastric cancer in a patient with acquired immunodeficiency syndrome

et al. 2010

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Total gastrectomy and chemotherapy with S-1 after surgery were performed in a 50-year-old woman with gastric cancer associated with acquired immunodeficiency syndrome (AIDS). She was given a diagnosis of gastric cancer at the lesser curvature of the body of the stomach, and distal gastrectomy was performed in December 2004. The postoperative course was eventful, with persistent high fever of unknown origin after surgery and infiltrative shadows in the bilateral lung fields showing on CT scan. Polymerase chain reaction (PCR) for pneumocystis carinii on bronchoscopy was positive, serum HIV antibody was positive, HIV-RNA was 2.2 × 10(5) copies/ml, and the serum CD4 lymphocyte level was 25/mm(3) on postoperative day 28. She was given a diagnosis of pneumocystis carinii with AIDS. Pneumocystis carinii and fever improved immediately when ST mixture and highly active antiretroviral therapy (HAART) were performed. After 3 months, the serum CD4 lymphocyte level was elevated to 125/mm(3), and she underwent total gastrectomy because cancer cells at the cut end of the resected stomach were positive microscopically. The postoperative course was uneventful, and she underwent adjuvant chemotherapy with S-1 because the serum CD4 lymphocyte level was 568/mm(3). S-1 therapy was continued for 2 years (each course consisting of 2 weeks of administration followed by 2 weeks off) while performing HAART and monitoring CD4 lymphocyte levels. No side effects such as decreases in white blood cell counts or CD4 lymphocyte levels were seen during S-1 therapy. She is alive and well without recurrence of gastric cancer 5 years after initial gastrectomy.

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Section: Discussionmentioning

confidence: 94%

Gastrectomy and chemotherapy with S-1 for gastric cancer in a patient with acquired immunodeficiency syndrome

et al. 2010

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Outcomes of Inguinal Hernioplasty in HIV-Positive Patients

Saito

Nishikawa

Asaoka

et al. 2021

Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi

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Purpose: Preoperative CD4 count is an indicator of outcome in human immunodeficiency virus (HIV)-positive patients who undergo surgery. The aim of this study was to compare the rate of postoperative complications in HIVpositive and HIV-negative patients. We also studied the effect of inguinal hernioplasty on HIV infection status. Materials and Methods: A retrospective study was performed in 316 patients who underwent inguinal hernioplasty from January 2008 and December 2012. Of these patients, 9 were HIV-positive. The rates of surgical site infection (SSI), bleeding, hematoma, seroma, recurrence, chronic pain, and period of hospitalization were compared in the HIV-positive and HIV-negative cases. Data were also collected for perioperative changes in HIV viral titers and CD4 counts in the HIV-positive group. Results: There were no significant differences in the rates of SSI, bleeding, hematoma, seroma, recurrence, chronic pain, and period of hospitalization between the two groups. The median preoperative viral titer and CD4 count were 40 copy/ml and 378 cells/mm 3 , respectively, and neither of these values changed significantly postoperatively. No patients developed opportunistic infections in the perioperative period. Conclusion: HIV-positive patients with a CD4 count >200 cells/mm 3 can safely undergo inguinal hernioplasty, similarly to HIV-negative patients.

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