Clinical Analysis of Patients With Low Voltage Eeg

Pine, Irving; Pine, Helen M.

doi:10.1097/00005053-195303000-00001

Cited by 12 publications

(3 citation statements)

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“…The low-voltage alpha EEG has been known to be heritable (autosomal dominant) and the heritability of alpha power is estimated at 79 to 93% (Anokhin et al, 1992;Beijsterveld & van Baal, 2002;Smit et al, 2010;Smit, Posthuma, Boomsma, & Geus, 2005;Vogel, 1970). Low-voltage EEG is a well-described endophenotype in anxiety and alcoholism (Bierut et al, 2002;Ehlers, Garcia-Andrade, Wall, Cloutier, & Phillips, 1999;Enoch, Schuckit, Johnson, & Goldman, 2003;Enoch et al, 1999;Pine & Pine, 1953). Alpha power and LVA have been successfully associated with a few chromosome loci but also with single genes: a serotonin receptor gene (HTR3B; Ducci et al, 2009), corticotrophin releasing binding hormone CRH-BP (Enoch, White, Waheed, & Goldman, 2008), a gammaamino butyric acid (GABA)-B receptor gene (Winterer et al, 2003), and with the BDNF Val66Met polymorphism in depression (Veth et al, 2012).…”

Section: Eeg As An Endophenotype?mentioning

confidence: 99%

EEG-Based Personalized Medicine in ADHD: Individual Alpha Peak Frequency as an Endophenotype Associated with Nonresponse

Arns¹

2012

Journal of Neurotherapy

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This review article summarizes some recent developments in psychiatry such as personalized medicine, employing biomarkers and endophenotypes, and developments collectively referred to as neuromodulation with a focus on ADHD. Several neurophysiological subtypes in ADHD and their relation to treatment outcome are reviewed. In older research the existence of an ''abnormal EEG'' or ''paroxysmal EEG'' was often reported, most likely explained by the high occurrence of this EEG subtype in autism, as the diagnosis of autism was not coined until 1980. This subgroup might respond best to anticonvulsant treatments, which requires more specific research. A second subgroup is a beta-excess or beta-spindling subgroup. This group responds well to stimulant medication, albeit several studies suggesting that neurophysiologically this might represent a different subgroup. The third subgroup consists of the ''impaired vigilance'' subgroup with the often-reported excess frontal theta or excess frontal alpha. This subgroup responds well to stimulant medication. Finally, it is proposed that a slow individual alpha peak frequency is an endophenotype related to treatment resistance in ADHD. Future studies should incorporate this endophenotype in clinical trials to further investigate new treatments for this substantial subgroup of patients, such as NIRSbiofeedback, transcranial Doppler sonography biofeedback, hyperbaric oxygen therapy, or medications such as nicotine and piracetam.

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Section: Eeg As An Endophenotype?mentioning

confidence: 99%

EEG-Based Personalized Medicine in ADHD: Individual Alpha Peak Frequency as an Endophenotype Associated with Nonresponse

Arns¹

2012

Journal of Neurotherapy

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“…(Gibbs et al 1953, Williams and Parsons-Smith 1950, Pine and Pine 1953, Vizioli 1955, M althijs 1961, Roth 1961, Vogel 1962, Friedlander 1962, Campanella and Tesi 1963, Walsa 1963a n d Synek 1967. Some o f th e se a u th o rs observed in low v o ltag e record episodic a c tiv ity a fte r h y p e rv e n tila tio n ( Pine andPine 1953, Campa nella andTesi 1963). Likew ise Walsa (1963) draw s a tte n tio n to th e fact th a t episodic a c tiv ity occurs in low voltage records from epileptics above all w hen th e p a tie n ts fall asleep and aw aken.…”

Section: Resultsmentioning

confidence: 99%

Low-voltage Electroencephalogram in Epilepsy

Synek¹

1968

Stereotact Funct Neurosurg

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“…In contrast with these facts, there is a small number of studies dealing specifically with the problem of LVR {Pine and Pine, 1953;Drechsler et al, 1955;Adams, 1959;Matthijs, 1961;Niedermeyer, 1961Niedermeyer, , 1963Vogel, 1962;Bfezinovâ, 1963;Campanella and Tessi, 1963;De Romanis, 1963;Deisenhammer, 1966;Walsa, 1963;Lucioni and Penati, 1966;Scherzer, 1966 andSynek, 1967). As yet, the occurrence of LVR was studied with respect to its relation to various diseases and various explicatory hypotheses were put for ward.…”

Section: Synekmentioning

confidence: 99%

The Possibilities of the Activation and Differentiation of Low-Voltage Electroencephalogram

Synek¹

1969

Int Pharmacopsychiatry

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In the present paper, the possibilities to activate low voltage EEG in 40 neuropsychiatrie patients have been discussed. An attempt at differentiation between two pathogenic factors, anxiety and lowered vigilance has been made. To activate the LVR, the blocking response, hyperventilation, bemegride administration, photostimulation, dexphenmetrazine, meprobamate and pharmacologically induced sleep have been used in all subjects. Altogether in 75 % of records, the amplitude of ground rhythm was successfully activated. The remaining 25 % did not respond to all activating methods and low voltage persisted even during sleep. Such was the case in organic lesions of CNS, particularly in vertebrobasilar insufficiency, where LVR may represent insufficiency of synchronizing mechanisms of brain rhythms.

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Clinical Analysis of Patients With Low Voltage Eeg

Cited by 12 publications

References 0 publications

EEG-Based Personalized Medicine in ADHD: Individual Alpha Peak Frequency as an Endophenotype Associated with Nonresponse

EEG-Based Personalized Medicine in ADHD: Individual Alpha Peak Frequency as an Endophenotype Associated with Nonresponse

Low-voltage Electroencephalogram in Epilepsy

The Possibilities of the Activation and Differentiation of Low-Voltage Electroencephalogram

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