Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia

Hu, Lijuan; Gong, Linjing; Jiang, Zhilong; Wang, Qibing; Zou, Yunzeng; Zhu, Liangliang

doi:10.1186/s13054-020-02933-3

Cited by 46 publications

(49 citation statements)

References 6 publications

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“…3 Others have written of bradycardia in adults with or without atrioventricular heart block as one of multiple cardiac complications in the setting of severe respiratory illness attributed to COVID-19. [4][5][6][7][8][9][10] Two papers speak specifically to associations between COVID-19 and relative bradycardia in adults, seen in states of high metabolic demand such as increased body temperature during which tachycardia would be expected. [11][12][13] One study found that one-third of adult patients with severe COVID-19 infection but overall stable vital signs developed sinus bradycardia at some point during the course of their illness.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13] One study found that one-third of adult patients with severe COVID-19 infection but overall stable vital signs developed sinus bradycardia at some point during the course of their illness. 4 Additionally, there are reports of adult patients infected with COVID-19 who develop bradycardia related to medications such as lopinavir-ritonavir, 14 hydroxychloroquine and other QT-interval-prolonging medications 15 and of course sedating medications. 16 Still, another case described bradycardia found with renal failure and electrolyte disturbances in the setting of BRASH syndrome in a COVID-19-positive adult patient.…”

Section: Discussionmentioning

confidence: 99%

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Sinus bradycardia in a toddler with multisystem inflammatory syndrome in children (MIS-C) related to COVID-19

et al. 2021

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This report documents a case of sinus bradycardia in a hospitalised 27-month-old girl with a history of moderate persistent asthma, recent suspected viral respiratory infection and suspicion for multisystem inflammatory syndrome in children (MIS-C). This patient developed profound sinus bradycardia during her hospitalisation despite an overall well clinical appearance and good outcome. Reports of bradycardia related to COVID-19 infection are few but growing in number. In this article, we discuss what has been observed in the literature about bradycardia in relation to COVID-19 and MIS-C. We also propose sinus bradycardia as a potential sign of MIS-C with recent respiratory symptoms, which would warrant close follow-up of such patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sinus bradycardia in a toddler with multisystem inflammatory syndrome in children (MIS-C) related to COVID-19

et al. 2021

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“…A recent report described the development of sinus bradycardia in 8 of 26 patients with severe COVID-19 pneumonia (without mentioning the presence of fever). The authors postulated an inhibitory effect of SARS-CoV-2 on sinus node activity [ 5 ].…”

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confidence: 99%

Relative bradycardia in patients with COVID-19

Capoferri

Osthoff

Egli

et al. 2021

Clinical Microbiology and Infection

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“…In particular, interleukin 6 plays a crucial role in the development of cytokine storm implicated in the progression of the infection and also increases vagal tone. Other possible postulated mechanisms are the impairment of autonomic control of HR caused by the toxic effect of SARS-CoV-2 on nervous system or a direct viral inhibitory effect on sinus node activity [5].…”

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confidence: 99%

Prevalence and clinical significance of relative bradycardia at hospital admission in patients with coronavirus disease 2019 (COVID-19)

Oliva

Franchi

Gatto

et al. 2021

Clinical Microbiology and Infection

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Heart rhythm disorders are increasingly reported during coronavirus virus disease 2019 and the presence of relative bradycardia (RB), known as an inappropriate low heart rate (HR) in response to an increased body temperature (BT), has been reported only occasionally [1]. However, its definition varied widely among studies and little is known regarding its role in predicting clinical outcomes [1,2]. We evaluated the prevalence and clinical significance of RB at hospital admission in patients with COVID-19. From March to September 2020, we performed a retrospective singlecentre study including all adult patients hospitalized at Policlinico Umberto I-Sapienza University (Rome) with confirmed COVID-19 (SARS-CoV-2 RNA detected by real-time PCR on nasopharyngeal swab). Exclusion criteria were treatment with HR-lowering agents and non-sinus rhythm at ECG. RB was defined as HR < 90 bpm and

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Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia

Cited by 46 publications

References 6 publications

Sinus bradycardia in a toddler with multisystem inflammatory syndrome in children (MIS-C) related to COVID-19

Sinus bradycardia in a toddler with multisystem inflammatory syndrome in children (MIS-C) related to COVID-19

Relative bradycardia in patients with COVID-19

Prevalence and clinical significance of relative bradycardia at hospital admission in patients with coronavirus disease 2019 (COVID-19)

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