Clinical analysis of synchronous primary neoplasms of the female reproductive tract

Tong, Seo-Yun; Lee, Yong-Sek; Park, Jong Sup; Bae, Seog Nyeon; Lee, Jun-Mo; Namkoong, Seung-Eun

doi:10.1016/j.ejogrb.2006.09.010

Cited by 81 publications

(85 citation statements)

References 17 publications

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“…The bulk of studies identified in this systematic review were retrospective cohort studies with <50 patients with SEOC (6-10, 12, 22, 24, 25, 28, 31, 34, 37, 38, 42, 44, 49, 51, 52, 55, 56, 58, 59, 61, 62, 65, 67-71), cases series of individual patients (13,23,35,36,43,45,66,73), and case reports (26,27,32,33,41,46,50,53,54,57,60,63,64,72,74,75). As expected, the heterogeneity among these studies with low numbers of patients was high.…”

Section: Immunohistochemical Stains Of An Endometrial Cancer Specimenmentioning

confidence: 99%

Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature

Doğan

Schultheis

Rezniczek

et al. 2017

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Abstract. Background: Young women with endometrial cancer (EC) have an increased risk of synchronous ovarian cancer. The prognosis of women with synchronous endometrial and ovarian cancer (SEOC) is good. A high proportion of affected women have hereditary non-polyposis colon cancer syndrome (HNPCCEndometrial cancer (EC) is the most common female pelvic malignancy with a life-time risk of 4% (1). It is usually diagnosed at an early stage and has a good prognosis accounting for only 2% of cancer-related deaths (1, 2). The most common age at the time of diagnosis is between 65 and 75 years with a mean age of 69 years (3). However, young women may also be affected by EC. Specifically, around 10% of women diagnosed with EC are <50 years of age with a range of 7 to 20% reported in the literature (1-4). This subset of women with EC is characterized by an elevated risk of synchronous ovarian cancer and an increased prevalence of hereditary non-polyposis colon cancer syndrome (HNPCC). This has important consequences for the management, prognosis, and genetic counselling of young women with EC.In the general population of women with EC, synchronous ovarian cancer is a rare finding. In a Surveillance, Epidemiology, and End Results Program (SEER) database analysis of 56986 women with ovarian cancer, for example, Williams et al. identified 1709 (3%) cases of synchronous endometrial and ovarian cancer (SEOC) (5). Young women with EC, however, have a significantly higher risk of SEOC with a range of 11 to 29% reported in the literature (4, 6-11). The typical histology of SEOC is endometrioid adenocarcinoma in both the endometrium and the ovary, which is found in >70% of cases (12). Based on this high rate of histological congruence among SEOC cases, a monoclonal origin has been suggested (13). Specifically, 969

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Section: Immunohistochemical Stains Of An Endometrial Cancer Specimenmentioning

confidence: 99%

Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature

Doğan

Schultheis

Rezniczek

et al. 2017

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“…Synchronous malignancies of the genital tract are rarely seen, most commonly involving ovary and endometrium [2,3], related with incessant ovulation, consequent oestrogen production, and continuous stimulation of the endometrium, with the consequent formation of neoplasms in these sites [4]. There are very few case reports in the literature reporting involvement of three (ovary, endometrium and cervix) or four (ovary, endometrium, cervix and fallopian tube) genital tract organs [5,6].…”

Section: Discussionmentioning

confidence: 99%

Aggressive Variety of Synchronous Carcinoma Cervix and Ovary

Rath¹,

Hadi²,

Singhal³

et al. 2017

JCR

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Background: Synchronous malignancies of ovary and cervix are rare and generally entail poor prognosis. The optimal management is not well defined and varies from case to case basis. Case Report: We present a case of synchronous malignancy of cervix and bilateral ovary, which initially masqueraded as a case of malignant ascites pointing towards ovarian carcinoma, but after surgical (total abdominal hysterectomy and bilateral salpingooophorectomy along with omentectomy) and histopathological evaluation was found to be a case of dual malignancy. Patient also received neoadjuvant and adjuvant paclitaxel and carboplatin, followed by full dose whole pelvis radiotherapy. But, the disease was aggressive in nature and progressed rapidly to involve liver, lung and multiple bony sites, inspite of adequate treatment. Conclusion: The possibility of a synchronous malignancy should also be considered while working on genital malignancy.

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“…[2] The most frequently encountered synchronous tumours of the female genital tract are ovarian (as in this case) and endometrial. [1] Although most are double, triple synchronous tumours have been reported. [2] Pathological screening of 957 benign cystic teratomas yielded nine multiple ipsilateral ovarian teratomas.…”

Section: Discussionmentioning

confidence: 99%

“…Synchronous tumours of the female genital tract, which are most often ovarian and endometrial, [1] are rare and account for only 0.7 -1.8% of all tumours. [2] The association of mature cystic teratoma with contralateral serous cystadenoma is uncommon.The most common benign germ cell tumours (GCTs) of the ovary are the mature cystic teratomas (MCTs).…”

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confidence: 99%

Bilateral synchronous benign ovarian neoplasm: A rare occurrence

et al. 2017

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CASE REPORTBilateral synchronous ovarian tumours are defined as the occurrence of two or more histologically distinct tumours in the ovaries. Synchronous tumours of the female genital tract are rare and the association of mature cystic teratoma with contralateral serous cystadenoma is uncommon. We report the rare occurrence of a giant mature cystic teratoma with a coexisting contralateral serous cystadenoma in a 32-year-old para 5. The patient refused an initial offer for surgery 10 years earlier, and had three successive term pregnancies and deliveries, with the tumour intact. She later had bilateral salpingo-oophorectomy of a 55 kg left ovarian mass and a 2 kg right ovarian mass, which revealed a left ovarian benign cystic teratoma and a right ovarian papillary serous cystadenoma at histology. Neglected ovarian tumours are still encountered in sub-Saharan Africa and may involve diagnostic and management challenges. There is a need to educate women and the community on ovarian neoplasms and the need to present early for effective management. Women's reproductive health rights need to be encouraged and possibly legislated in our setting.

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Clinical analysis of synchronous primary neoplasms of the female reproductive tract

Cited by 81 publications

References 17 publications

Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature

Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature

Aggressive Variety of Synchronous Carcinoma Cervix and Ovary

Bilateral synchronous benign ovarian neoplasm: A rare occurrence

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