Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: A retrospective study

Cao, Dongmei; Yin, Heng; Chen, Jun; Tang, Fei; Peng, Min; Li, Ruobing; Xie, Hui; Wei, Xiaoying; Zhao, Yun; Sun, Guoqiang

doi:10.1016/j.ijid.2020.04.047

Cited by 98 publications

(117 citation statements)

References 19 publications

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“…The highest preterm percent was in a research investigated cases of pregnant patients with severe coronavirus-2 respiratory infections which was about (90%) (Hantoushzadeh et al, 2020). While premature membrane rupture, the highest incidence was in three studies (Cao et al, 2020;Wu et al, 2020;Zhu et al, 2020). Stillbirth was the least complication, two cases of stillbirth was detected in this review in two studies due to severe maternal infections (Liu et al, 2020c;Lokken et al, 2020).…”

Section: Discussionmentioning

confidence: 66%

“…After assessment of abstracts and methods to determine eligible articles; Total 57 articles were excluded (the reasons either no cases included, review articles or symptoms and outcomes were not investigated). The remaining 25 articles are found to be eligible (Breslin et al, 2020a;Breslin et al, 2020b;Cao et al, 2020;Chen et al, 2020a;Chen et al, 2020b;Chen et al, 2020c;Fan et al, 2020;Govind et al, 2020;Hantoushzadeh et al, 2020;Hirshberg et al, 2020;Khan et al, 2020;Liu et al, 2020a;Liu et al, 2020b;Liu et al, 2020c;Lokken et al, 2020;Lu et al, 2020;Pierce-Williams et al, 2020;Polónia-Valente et al, 2020;Wang et al, 2020;Wen et al, 2020;Wu et al, 2020;Xu et al, 2020;Yu et al, 2020;Zambrano et al, 2020;Zhu et al, 2020); they consist of letters, case reports or series, and research articles.…”

Section: Resultsmentioning

confidence: 99%

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Clinical manifestations and maternal outcomes of COVID-19 in pregnancy: A systematic review

Ahmed¹,

Ahmed²

2020

Asian J Pharm Pharmacol

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Aim of present work was to summarize existing proof of clinical presentation, symptoms and maternal outcomes of coronavirus-2 throughout pregnancy. Methods Science Direct, PubMed, and Google Scholar have been searched for relevant researches published from January 1, 2020 to June 30, 2020, and the following search according to Medical Subject Headings (MeSH) terms was applied in each database accordingly: "clinical features," "manifestations," "outcomes, maternal outcomes" "COVID

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Section: Discussionmentioning

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Clinical manifestations and maternal outcomes of COVID-19 in pregnancy: A systematic review

Ahmed¹,

Ahmed²

2020

Asian J Pharm Pharmacol

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“…Seventeen were case series ( n = 453 pregnancies) [ 23 , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] ], five were cohort studies ( n = 631 pregnancies) [ 17 , [41] , [42] , [43] , [44] ], and one was a case–control study ( n = 16 pregnancies) [ 45 ] ( Supplementary Material Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis

Toro

Gjoka

Lorenzo

et al. 2021

Clinical Microbiology and Infection

293

226

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Background Previous outbreaks of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and Middle East respiratory syndrome coronavirus (MERS-CoV) have been associated with unfavourable pregnancy outcomes. SARS-CoV-2 belongs to the human coronavirus family, and since this infection shows a pandemic trend it will involve many pregnant women. Aims This systematic review and meta-analysis aimed to assess the impact of coronavirus disease 19 (COVID-19) on maternal and neonatal outcomes. Sources PubMed, EMBASE, MedRxiv, Scholar, Scopus, and Web of Science databases were searched up to 8th May 2020. Articles focusing on pregnancy and perinatal outcomes of COVID-19 were eligible. Participants were pregnant women with COVID-19. Content The meta-analysis was conducted following the PRISMA and MOOSE reporting guidelines. Bias risk was assessed using the Joanna Briggs Institute (JBI) manual. The protocol was registered with PROSPERO (CRD42042020184752). Twenty-four articles, including 1100 pregnancies, were selected. The pooled prevalence of pneumonia was 89% (95%CI 70–100), while the prevalence of women admitted to the intensive care unit was 8% (95%CI 1–20). Three stillbirths and five maternal deaths were reported. A pooled prevalence of 85% (95%CI 72–94) was observed for caesarean deliveries. There were three neonatal deaths. The prevalence of COVID-19-related admission to the neonatal intensive care unit was 2% (95%CI 0–6). Nineteen out of 444 neonates had a positive nasopharyngeal swab; one out of five neonates had elevated concentrations of serum IgM and IgG, but a negative swab. Implications Although adverse outcomes such as ICU admission or patient death can occur, the clinical course of COVID-19 in most women is not severe, and the infection does not significantly influence the pregnancy. A high caesarean delivery rate is reported, but there is no clinical evidence supporting this mode of delivery. Indeed, in most cases the disease does not threaten the mother, and vertical transmission has not been clearly demonstrated. Therefore, COVID-19 should not be considered as an indication for elective caesarean section.

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“…Five of the newborns underwent COVID-19 testing, and none of them were tested positive. The study concluded that COVID-19 is not an indication for caesarean section [41].…”

Section: Clinical Features In Pregnant Womenmentioning

confidence: 92%

The SARS-CoV-2 Outbreak: an Epidemiological and Clinical Perspective

Wong

2020

SN Compr. Clin. Med.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started with the detection of an increasing number of pneumonia cases of unknown origin in Wuhan, China, since December 2019. The disease caused by SAS-CoV-2 was subsequently named coronavirus disease 2019 (COVID-19). Currently, the ongoing COVID-19 pandemic poses a global health concern with more than 28.9 million confirmed cases, taking away the lives of more than 900,000 people worldwide. To prevent further spread of the disease, an understanding of the clinical characteristics and how the disease spread is essential, especially for an emerging disease like COVID-19. Individuals who are infected with SARS-CoV-2 show diverse clinical features, and the disease severity can range from asymptomatic to death. The disease has been shown to affect not just the respiratory system but also other systems of the body. This review will discuss the pulmonary and extra-pulmonary clinical manifestations of COVID-19 in general, as well as the clinical characteristics in different groups of patients such as children, the elderly, pregnant women, patients with comorbidities and those with a compromised immunity. It will also critically examine existing evidence from relevant studies and discuss the SARS-CoV-2 outbreak from an epidemiological perspective. With the easing of control measures in many countries after months of lockdown, it is important to revisit the lessons learnt from research, as the world enters a new normal with the coexistence of SARS-CoV-2.

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Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: A retrospective study

Abstract: Background: COVID-19 is spreading globally. This study aims to evaluate the clinical characteristics and outcomes of pregnant women confirmed with COVID-19 to provide reference for clinical work. Methods: The clinical features and outcomes of 10 pregnant women confirmed with COVID-19 at

Cited by 98 publications

References 19 publications

Clinical manifestations and maternal outcomes of COVID-19 in pregnancy: A systematic review

Clinical manifestations and maternal outcomes of COVID-19 in pregnancy: A systematic review

Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis

The SARS-CoV-2 Outbreak: an Epidemiological and Clinical Perspective

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