Clinical analysis of the efficacy of interferon alpha treatment of hepatitis

Zhu, Ying; Wang, Ying-Lan; Shi, Long

doi:10.3748/wjg.v4.isuppl2.99

Cited by 9 publications

(1 citation statement)

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“…Viral hepatitis is relatively common in China [1][2][3][4][5][6][7][8][9][10][11][12] . Among them hepatit is G virus (HGV) and hepatitis GB virus (GBV-C) were recently identified as the two isolates of a novel positive-stranded RNA virus belonging to Flaviviridae family associated with human non-A-E hepatitis [13,14] .…”

Section: Introductionmentioning

confidence: 99%

High frequencies of HGV and TTV infections in blood donors in Hangzhou

Yan¹,

Chen²,

Luo³

et al. 2001

WJG

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AIM To determine the frequencies of HGV and TTV infections in blood donors in Hangzhou.METHODS RT-nested PCR for HGV RNA detection and semi-nested PCR for TTV DNA detection in the sera from 203 blood donors, and nucleotide sequence analysis were performed.RESULTS Thirty-two (15.8%) and 30 (14.8%) of the 203 serum samples were positive for HGV RNA and TTV DNA, respectively. And 5 (2.5%) of the 203 serum samples were detectable for both HGV RNA and TTV DNA. Homology of the nucleotide sequences of HGV RT-nested PCR products and TTV semi-nested PCR products from 3 serum samples compared with the reported HGV and TTV sequences was 89.36%, 87.94%, 88.65% and 63.51%, 65.77% and 67.12%, respectively.CONCLUSION The infection rates of HGV and/or TTV in blood donors are relatively high, and to establish HGV and TTV examinations to screen blood donors is needed for transfusion security. The genomic heterogeneity of TTV or HGV is present in the isolates from different areas.Subject headings China; DNA virus infections/epidemiology; hepatitis, virus, human/ epidemiology; blood transfusion/ adverse effect; blood donors; hepatitis agents, GB/ isolation & purification

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Section: Introductionmentioning

confidence: 99%

High frequencies of HGV and TTV infections in blood donors in Hangzhou

Yan¹,

Chen²,

Luo³

et al. 2001

WJG

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A Randomized, Controlled, Clinical Study of Thymosin Alpha-1 Versus Interferon-Alpha in Chinese Patients with Chronic Hepatitis B Lacking Hepatitis B Envelope Antigen

You

Zhang

Cheng

et al. 2005

Journal of the Chinese Medical Association

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These results suggest that a 6-month course of T-alpha1 therapy is effective and safe in patients with anti-HBe-positive chronic hepatitis B; T-alpha1 can reduce HBV replication in such patients. Compared with IFN-alpha, T-alpha1 is better tolerated and seems to induce a gradual and more sustained normalization of ALT and loss of HBV DNA. Combination therapy with T-alpha1 and IFN-alpha or nucleoside analogs for hepatitis B warrants further study.

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