The article presents a review of the literature and a comparative analysis of the methods of radiation diagnostics of osteomyelitis in children. Active improvement of devices and research methods for more effective diagnosis of diseases continues. Cone beam computed tomography (CBCT) can provide specialists with the necessary diagnostic information, and its use will reduce the radiation exposure received by patients during the study. This publication demonstrates 2 clinical cases where CBCT was chosen as the diagnostic method. These observations will demonstrate the possibilities of CBCT in the diagnosis of osteomyelitis and dynamic monitoring in children and adolescents.