Clinical and anti‐inflammatory effects of treating endotoxin‐challenged pigs with meloxicam

Friton, Gabriele M; Schmidt, Hauke; Schrödl, Wieland

doi:10.1136/vr.159.17.552

Cited by 18 publications

(24 citation statements)

References 7 publications

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“…(Klosterhalfen et al, 1992;Mustonen et al, 2012). However, Friton et al (2006) established a maximal TXB 2 concentration only at 2 h p.a. of LPS, while Peters et al (2012) detected no increase at all in pigs.…”

Section: Thromboxane B 2 and Pulmonary Hypertensionmentioning

confidence: 91%

“…(Johnson and von Borell, 1994). Pretreatment of pigs with meloxicam or flunixin meglumine significantly decreased the clinical symptoms induced by LPS-challenge, including lethargy, skin flushing, vomiting, coughing and labored breathing (Friton et al, 2006;Peters et al, 2012). Different oral doses of ketoprofen p.a.…”

Section: Effects On Clinical Symptoms and Febrile Responsementioning

confidence: 98%

“…As for the cytokines, commercial ELISA kits are popular for the determination of prostaglandins and thromboxanes (Friton et al, 2006;Cao et al, 2006;Mustonen et al, 2012;Peters et al, 2012). Although these methods are sensitive, they are not very specific.…”

Section: Thromboxane B 2 and Pulmonary Hypertensionmentioning

confidence: 99%

See 2 more Smart Citations

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Wyns

Plessers

Backer

et al. 2015

Veterinary Immunology and Immunopathology

102

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Section: Thromboxane B 2 and Pulmonary Hypertensionmentioning

confidence: 91%

Section: Effects On Clinical Symptoms and Febrile Responsementioning

confidence: 98%

See 1 more Smart Citation

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Wyns

Plessers

Backer

et al. 2015

Veterinary Immunology and Immunopathology

102

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“…Regarding NSAIDs, a study conducted in rats and mice found that the therapeutic index of meloxicam is higher than that of other NSAIDs, including piroxicam, diclofenac and indomethacin. Meloxicam, an NSAID of the oxicam class, acts by inhibiting prostaglandin synthesis (Engelhardt and Trummlitz, 1990) and inducible cyclo-oxygenase-2 (COX-2; Engelhardt, 1996), thereby exerting anti-inflammatory, antitoxic, antiexudative, analgesic and antipyretic effects (Friton et al, 2006). Meloxicam is used for noninfectious locomotor disorders in pigs, by reducing the signs of lameness and inflammation (Friton et al, 2003), the porcine respiratory disease complex in growing pigs (Georgoulakis et al, 2006) and for the relief of post-operative pain associated with minor soft tissue surgery such as castration (Keita et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of meloxicam (Metacam®) on post-farrowing sow behaviour and piglet performance

Mainau

Ruiz-de-la-Torre

Dalmau

et al. 2012

Animal

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Farrowing is an intrinsically risky process for both the sow and the piglets that can cause welfare and economic problems. The effects of the non-steroidal anti-inflammatory drug meloxicam on post-farrowing behaviour of sows, and the performance of piglets were investigated. A total of 48 sows were randomly allocated at the day of farrowing (day 0) into two homogeneous groups regarding parity, and treated with either meloxicam or saline solution as placebo. For each sow, number of position changes, total time lying and standing or sitting, feed intake and rectal temperature (RT) were recorded during 3 days after farrowing. Piglets were individually weighed at farrowing and at weaning. The number of position changes did not show significant differences between treatments (P 5 0.79). Sows spent significantly less time lying during day 13 after farrowing in the meloxicam group than in the placebo group (P 5 0.04). Feed intake and RT showed a parity effect (P , 0.001 in both cases); however, no treatment effect was observed (P 5 0.67 and P 5 0.47, respectively). Pre-weaning mortality rate in piglets was not affected by treatment. In litters from multiparous sows, piglets of low birth weight (defined as percentile 15: BW ,1180 g) had an average daily gain significantly higher in the meloxicam group than in the placebo group (196.6 6 7.2 v. 166.6 6 9.1 g/day; P 5 0.03). Although the administration of meloxicam 90 min after farrowing showed a positive effect on the total time lying of the sows, additional investigations are required to better qualify relevant indicators of pain following farrowing in sows and to specify the analgesic effects of meloxicam on piglet performance.

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“…for the pharmacokinetic and pharmacodynamic study of meloxicam in piglets. The same single dose of meloxicam in adult pigs was used by Swindle (2007) and Friton et al (2006) in endotoxemia therapy and by Hirsch et al (2003) in mastitis-metritis-agalactia syndrome therapy. A similar dosage (0.3 mg/kg) was administered by Girod et al (2000Girod et al ( , 2002 in their studies on the antiemetic effects of meloxicam.…”

Section: Discussionmentioning

confidence: 99%

Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs

Raušer¹,

Stehlík²,

Proks³

et al. 2010

Vet. Med.

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Carprofen or meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs), which may elicit a variety of renal disturbances. Prior to this study, the effects of carprofen or meloxicam on renal function in pigs were unknown. A total of 21 clinically healthy Goettingen miniature pigs (36.9 ± 7.22 kg) were divided into three groups based on what they were administered -carprofen, meloxicam or saline. First, blood was collected from the jugular vein and urine by ultrasound-guided cystocentesis. Serum urea (U) and creatinine (CR), fractional clearance of sodium (FCNa), urine gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities, urine protein/creatinine ratio (UP/UC), urine gamma-glutamyltransferase/creatinine ratio (GGT/CR) and urine alkaline phosphatase/creatinine ratio (ALP/CR) and urine analysis -urine specific gravity (USG) and sediment microscopy were assessed before and seven days after daily intramuscular administration (IM) of saline (1.5 ml per animal), carprofen (2 mg/kg) or meloxicam (0.1 mg/kg). All animals had identical housing, feeding and unlimited water intake and had not undergone surgery or been administered any medication for three months prior to this. All pigs served as control groups for an experimental study of fracture healing using transplantation of mesenchymal stem cells and scaffolds. The data were analyzed using a one way ANOVA and a Mann-Whitney test (P < 0.05). In pigs receiving carprofen, serum urea and creatinine were significantly decreased, compared to the control (P < 0.01) or meloxicam (P < 0.05) groups. In animals receiving meloxicam FCNa was significantly increased (P < 0.05) and urine specific gravity significantly decrease (P < 0.05) compared to the pretreatment values. Two carprofentreated pigs had a slight increase in renal tubular epithelial cells upon urine sediment examination. Intramuscular administration of carprofen or meloxicam in healthy miniature pigs for seven days causes no clinically important changes in selected renal parameters (without azotemia). However these changes indicate mild damage of renal tubules. Despite these findings, meloxicam or carprofen are recommended for analgesia in healthy pigs.

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Clinical and anti‐inflammatory effects of treating endotoxin‐challenged pigs with meloxicam

Cited by 18 publications

References 7 publications

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Effects of meloxicam (Metacam®) on post-farrowing sow behaviour and piglet performance

Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs

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