Clinical and antimicrobial efficacy of a controlled-release device containing chlorhexidine in the treatment of chronic periodontitis

Abstract

A controlled-release device (CRD) containing chlorhexidine gluconate, such as PerioCol(™)CG (Eucare Pharmaceuticals Pvt. Ltd,, Chennai, India), for subgingival application has little reported data with clinical as well as antimicrobial efficacy. This study evaluated clinical and subgingival microbial changes on using indigenously developed PerioCol™CG as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. Forty posterior first molar sites having probing pocket depth ≥ 5 mm were selected and divided into two groups, with 20 sites in each group, in a split-mouth design. Group A (test site) was treated with SRP and PerioCol(™)CG, while group B (control site) was treated with SRP alone. Subgingival microbial samples were collected at baseline and 1 month after the initial SRP, while probing depth (PD), clinical attachment level (CAL) and gingival index (GI) were recorded at baseline, after 1 month and after 3 months. Microbial detection of Porphyromonas gingivalis (P. gingivalis) and Tannerella forsythia (T. forsythia) was done by means of polymerase chain reaction (PCR). A significant improvement was observed in all clinical measures in sites treated with PerioCol(™)CG as compared to the control sites during the study period. Also, there was a statistically significant reduction in the proportion of occurrence of P. gingivalis and T. forsythia after intervention in test sites as compared to control sites. Our data suggest that SRP combined with subgingival administration of PerioCol™CG has a significantly better and prolonged effect compared to SRP alone on the PD, clinical attachment loss and elimination of periodontopathogens.

Effect of sodium ascorbyl phosphate on osteoblast viability and differentiation

“…In view of the findings presented herein, there could be a potential role for SAP incorporated into controlled release devices or scaffolds/membranes, as reported in the medical literature with the use of poly‐lactic acid frameworks for pelvic floor reconstruction 44 . Such controlled release devices could be used in periodontal pockets after conservative scaling and root planing to enhance periodontal healing 45,46 or to prevent or treat peri‐implantitis, 47 whereas membranes or scaffolds loaded with SAP could be used to optimize guided tissue or bone regeneration 48‐50 . The use of SAP instead of AA in its pure form may confer protection against the challenging environment seen in the periodontium.…”

Effect of chlorhexidine chip as an adjunct in non-surgical management of periodontal pockets: a meta-analysis

“…We found eight studies [ 20 , 21 , 27 – 30 , 32 , 33 ] with moderate and four [ 17 , 24 – 26 ] with low risk of bias. Three of the trials [ 22 , 23 , 31 ] had high risks of bias due to lack of information or inappropriateness regarding allocation concealment and blinding of participants, personnel, or outcome assessors (Fig.…”

A Novel Complementary Alternative Medicine: An In-Vitro Evaluation of Efficacy of Nigella sativa Extract as an Antibacterial Agent against Porphyromonas gingivalis

“…Evidence from several researches has implicated that this specific bacteria plays a key role in the pathogenesis of chronic periodontitis. 19 In this study, subgingival biofilms of seventy three patients having chronic periodontitis were screened for the presence of P. gingivalis. 42.46% of the patients were detected to harbor P. gingivalis in their subgingival plaque samples.…”