1992
DOI: 10.1016/0264-410x(92)90347-m
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Clinical and bacteriological studies of El Tor cholera after ingestion of known inocula in Thai volunteers

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Cited by 17 publications
(13 citation statements)
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“…19 20 Indeed, many of the LMIC HCS published in recent decades were focused on understanding locally relevant aspects of host-pathogen interaction without necessarily involving the testing of interventions such as vaccines. [23][24][25][26][27][28][29][30] Thus, in terms of benefits to be shared, it may be more relevant to consider the importance of generating locally relevant knowledge and the overall long-term expected benefits from a programme of research as a whole (rather than a single study in isolation) 31 especially in cases where there are future plans to test potentially beneficial interventions (so long as there is reasonable confidence that the programme can/will continue).…”
Section: Benefit Sharingmentioning
confidence: 99%
“…19 20 Indeed, many of the LMIC HCS published in recent decades were focused on understanding locally relevant aspects of host-pathogen interaction without necessarily involving the testing of interventions such as vaccines. [23][24][25][26][27][28][29][30] Thus, in terms of benefits to be shared, it may be more relevant to consider the importance of generating locally relevant knowledge and the overall long-term expected benefits from a programme of research as a whole (rather than a single study in isolation) 31 especially in cases where there are future plans to test potentially beneficial interventions (so long as there is reasonable confidence that the programme can/will continue).…”
Section: Benefit Sharingmentioning
confidence: 99%
“…A large inoculum of V. cholerae is required to infect an individual (Cash et al, 1974; Levine et al, 1979; Suntharasamai et al, 1992), which makes ciclo corto transmission appear to be physiologically challenging. There are several possible mechanisms for transmission within a household.…”
Section: 2 Mathematical Models Of Cholera Transmissionmentioning
confidence: 99%
“…19 Escalating doses of 10 3 to 10 6 cfu of El Tor Inaba strain N16961 with sodium bicarbonate were given to 26 volunteers. Infection, diarrhea, and serologic responses were seen with doses as low as 10 3 vibrios, and the severity of illness was directly proportional to the inoculum size.…”
Section: Challenge Modelsmentioning
confidence: 99%
“…Inoculation of 1.3 × 10 7 organisms produced a diarrheal attack rate of 90%, though clinical illness appeared milder than that seen in the prior studies with North American volunteers. 19 To improve consistency among challenge studies, a model of cholera with frozen challenge bacteria was also validated. 21 …”
Section: Challenge Modelsmentioning
confidence: 99%