Clinical and biochemical effects of spironolactone administered once daily in primary hypertension. Multicenter Sweden study.

Abstract

The aim of the present multicenter study is to investigate the effects of once-daily regimens of 50, 100, and 200 mg spironolactone in outpatients with mild or moderate primary (essential) hypertension. Special reference is made to dose-response relationships between blood pressure (BP) changes, demographic,

Does Aldosterone-to-Renin Ratio Predict the Antihypertensive Effect of the Aldosterone Antagonist Spironolactone?

“…6,7 In a dose-response study patients given 50 to 200 mg of spironolactone, it was shown that those with the greater response to spironolactone were characterized by older age and low plasma renin activity. 12 Our data confirms this finding, which is not unexpected, inasmuch as older hypertensive patients tend to have low renin values. However we found that the relationship to ARR persisted when adjusted for age.…”

Metabolic Effects of Diuretics

“…A second mechanism is suppression of insulin secre tion, which in turn is related to hypokalaemia. Spironolactone does not elevate blood glucose levels even at doses that cause volume deple tion equivalent to that with thiazide treat ment [11], suggesting that changes in potas sium homoeostasis may be fundamental to the changes in glucose tolerance.…”

Effect of diuretics on the plasma lipid profile

“…In recent years it has become three agents, have lowered blood pressure effectively. evident that several of the dm & used for standard antl " Such therapy also improves overall cardiovascular and, in hypertensi wtherapy may interact with the lipoprotein particular, cerebrovascular prognosis, but has had less metabolism benefit on the course of coronary heart disease and the incidence of sudden death 1 '" 41 . In patients with mild hyper-__ ... , .…”