Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic

“…Among 68 deaths in a case series of 150 patients with COVID-19, 7% were attributed to myocarditis with circulatory failure and in 33% of cases which myocarditis may have played a contributing role to the patient's demise (21). Other reports have described fulminant myocarditis in the setting of high viral load with autopsy findings of inflammatory mononuclear infiltrate in myocardial tissue (26,47,48). Pericardial involvement has not yet been reported but further study is needed.…”

“…While extensive CV toxicities and medication interactions have yet to be reported, prior evaluation of this drug during the Ebola outbreak did note the development of hypotension and subsequent cardiac arrest after loading dose in one patient (among 175 total) (75). Methylprednisolone is another drug under investigation that is currently being used to treat severe cases of COVID-19 that are complicated by ARDS (48). This steroid is known to cause fluid retention, electrolyte derangement, and hypertension as direct CV effects, and also may interact with warfarin via an undescribed mechanism.…”

Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis

“…Overall, 98 documents could be initially identified based on our search criteria and from the reference lists, 89 of which were excluded after title, abstract or full text reading, since they were review articles (n=8), commentaries or other editorial materials (n=2), they did not deal with COVID-19 disease (n=71), or did not expressly reported the number of platelets and/or the rate of thrombocytopenia in COVID-19 patients with or without severe disease (n=8). Therefore, 9 studies could finally be included in our metaanalysis, totaling 1779 COVID-19 patients, 399 of whom (22.4%) with severe disease [11][12][13][14][15][16][17][18][19].…”

“…Eight studies included Chinese patients, whilst one was based in Singapore [18]. The clinical severity was defined as the composite of ICU admission, use of mechanical ventilation or death in two studies [11,13], ICU admission in two studies [12,16], progression towards ARDS in one study [14], death in three studies [15,17,19], and need of mechanical ventilation in the remaining study [18]. All eight studies provided data on the platelet count, whilst only four studies provided information on the rate of thrombocytopenia [11,12,14,19], where thrombocytopenia was defined as platelet count <15010 9 /L in two studies [11,14], whilst was set at <10010 9 /L in the other two investigations [12,19].…”

Chronic obstructive pulmonary disease is associated with severe coronavirus disease 2019 (COVID-19)

“…Overall, 87 articles were initially identified based on our electronic and reference search, which after screening by tile, abstract, and full text, 80 were excluded as not related to COVID-19 (n=27), were review articles (n=7), did not provide relevant data (n=28), were editorials (n=10), did not provide data on severity or comorbidities (n=5), compared patients by mortality not severity (n=2) or compared mild cases to critical cases (n=1). Thus, a total number of 7 studies were finally included in our meta-analysis, totaling 1,592 COVID-19 patients, 314 of which (19.7%) had severe disease [6][7][8][9][10][11][12].…”