Clinical and biochemical profile of liver abscess patients

Jain, Vineet; Manjavkar, Smita; Kapur, Prem; Durfishan,; Rajput, Divya; Mir, Tanveer

doi:10.18203/2320-6012.ijrms20172454

Cited by 4 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The commonest clinical presentation observed in the study by Dhanapal PV et al was abdominal pain which was found in 100% of cases which was followed by abdominal distension and fever in about half of the cases. 15 This is also similar to the observations made by Jain V et al, Kemparaj P et al, and Kebede A et al 9,12,14…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Clinical Profile, Complications and Current Management of Amoebic Liver Abscess- A Study of 100 Consecutive Cases

Chaudhari¹,

Prajapati²,

Khan³

2019

jebmh

View full text Add to dashboard Cite

BACKGROUNDAmoebic Liver Abscess (ALA) in the Indian population has been relatively common and continues to have a significant morbidity in terms of days lost from work. The mortality rate of ALA cases reported to be around 11%-14% before 1984 and has reduced to around 1% at present. This article aims to review the trends in the clinical aspects of ALA in adult patients. METHODSThis is a study of 100 consecutive patients diagnosed with liver abscess at a tertiary care center in Western India which were followed up in a prospective manner during their hospital stay and during readmissions. Ultrasonography (USG) and Computed Tomography (CT) were used as diagnostic tools. A pre-decided protocol of management was followed. All patients with unruptured abscesses with size less than 5 cms were given a trial of oral/IV anti-amoebic medications. Larger ones were drained under the cover of medications. Open surgical interventions were reserved for ruptured abscesses and for patients with toxic symptoms. Laparoscopic drainage was instituted for abscesses not responding to aforementioned conservative methods. RESULTSMean hospital stay was 13.4 days with length of stay ranging from 2 to 35 days (S.D. 8.4 days). 100 patients were included in the study. Right lobe involvement was seen in 70% cases while left lobe was involved in 9% cases. Bilateral lobar involvement was seen in 5% cases. 22 patients had more than one ALA. 16% of patients presented with ruptured liver abscess where open surgical drainage was done. Eight patients were put on conservative treatment with intravenous metronidazole, of which, 4 patients responded well to conservative treatment while 4 patients failed to respond to treatment and their abscesses were aspirated. Aspiration along with antibiotics was performed in 76% cases as first line of therapy. Two patients who underwent emergency laparotomy for ruptured ALA, died. CONCLUSIONSAetiology of LA in children has remained the same over the years, and in most regions, it is associated with Staphylococcus aureus and amoebic LA is quite uncommon. US or CT scan are the most frequently employed diagnostic modalities for LA, and follow-up is usually performed by serial US scans. Antimicrobial therapy along with drainage of the abscess by either percutaneous or open surgical route, if required remains the treatment of choice.

show abstract

Section: Discussionsupporting

confidence: 83%

“…12,13 Jain V et al observed Pleural effusion was seen in 12% (n=6) cases whereas ascites was observed in 6% cases. 14 In a study by Dhanapal PV et al most of the liver abscess cases were managed with interventions. 15 About 30% of cases were treated by single aspiration and 20% of cases by multiple aspirations.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile, Complications and Current Management of Amoebic Liver Abscess- A Study of 100 Consecutive Cases

Chaudhari¹,

Prajapati²,

Khan³

2019

jebmh

View full text Add to dashboard Cite

show abstract

“…In present study alcohol consumption was seen as a major risk factor as 55.0% patients of ALA were exposed to it. Jain V et al & Ghosh et al 2,5 had 58.4 % & 72% alcoholic patients in their study respectively. Alcohol suppresses function of Kupffer cells (specialized macrophage) in liver which has important role in clearing amoeba.…”

Section: Discussionmentioning

confidence: 71%

Clinical Profile and Management of Patients of Amoebic Liver Abscess in a Tertiary Care Centre

Mishra¹,

Banerjee²,

Jana

2020

ijsr

View full text Add to dashboard Cite

Introduction: Amoebiasis is caused by the protozoan Entamoeba histolytica. Most infections are asymptomatic; clinical manifestations include amoebic dysentery and extra intestinal disease. Amoebic liver abscess is the most common extraintestinal manifestation of amoebiasis. Amoebae establish hepatic infection by ascending the portal venous system. Aim: To study various aspects of Amoebic Liver Abscess like demographic profiles, clinical presentations, association with intestinal disease, radiological and laboratory findings, treatment modalities and complications. Materials and Methods: A hospital based prospective observational study was performed in the Department of Internal Medicine, Command Hospital (Eastern Command), Kolkata, from Jan 2018 to Jun 2019. All confirmed cases of amoebic liver abscess above the age of 18 years admitted in Command Hospital (EC) were included in this study. The patient were then subsequently followed up for 01 year with USG abdomen every 03 monthly. Results: Total 40 patients of Amoebic Liver Abscess with age more than 18 year were enrolled in the study. The age ranged from 26 to 70 years (mean age 46.2 year). Male patients were dominated over female. 80.0 % were from rural background. About 55% patients were addicted to alcohol & 25.0 % were known diabetics at presentation. In all, 07 (17.5%) patients with abscess size of 6 cm to 10 cm (Vol> 300 cc) were treated by needle aspiration and drug therapy. Remaining 17(42.5%) patients with abscess size more than 10 cm were treated with pigtail drainage and drug. Conclusion: There is significant advantage of pigtail drainage with drug treatment over needle aspiration with drug and only with drug treatment in terms of decrease in lesion size and early recovery.

show abstract