Clinical and biochemical short-term effects of hyperbaric oxygen therapy on SARS-Cov-2+ hospitalized patients with hypoxemic respiratory failure

Keller, Guillermo Alberto; Colaianni, Ivana; Coria, Javier; Girolamo, Guillermo Di; Miranda, Silvia

doi:10.1016/j.rmed.2023.107155

Cited by 7 publications

(5 citation statements)

References 40 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low oxygen saturation is known in hypoxic cases. Keller et al reported that COVID‐19‐related hypoxia is associated with high plasma LDH and D dimer values 21 . Increased plasma LDH levels have been associated with acute respiratory distress syndrome (ARDS), intensive care unit support, and an increased risk of death 22 …”

Section: Discussionmentioning

confidence: 99%

Microstructural alterations in hypoxia‐related BRAIN centers after COVID‐19 by using DTI: A preliminary study

Balsak,

Atasoy,

Donmez

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

PurposeTo investigate whether the diffusion tensor imaging (DTI) parameters alterations in the in hypoxia‐related neuroanatomical localizations in patients after COVID‐19. Additionally, the relationship between DTI findings and the clinical severity of the disease is evaluated.MethodsThe patients with COVID‐19 were classified into group 1 (total patients, n = 74), group 2 (outpatient, n = 46), and group 3 (inpatient, n = 28) and control (n = 52). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were calculated from the bulbus, pons, thalamus, caudate nucleus, globus pallidum, putamen, and hippocampus. DTI parameters were compared between groups. Oxygen saturation, D dimer and lactate dehydrogenase (LDH) values associated with hypoxia were analyzed in inpatient group. Laboratory findings were correlated with ADC and FA values.ResultsIncreased ADC values in the thalamus, bulbus and pons were found in group 1 compared to control. Increased FA values in the thalamus, bulbus, globus pallidum and putamen were detected in group 1 compared to control. The FA and ADC values obtained from putamen were higher in group 3 compared to group 2. There was a negative correlation between basal ganglia and hippocampus FA values and plasma LDH values. The ADC values obtained from caudate nucleus were positively correlated with plasma D Dimer values.ConclusionADC and FA changes may reveal hypoxia‐related microstructural damage after COVID‐19 infection. We speculated that the brainstem and basal ganglia can affected during the subacute period.

show abstract

Section: Discussionmentioning

confidence: 99%

Microstructural alterations in hypoxia‐related BRAIN centers after COVID‐19 by using DTI: A preliminary study

Balsak,

Atasoy,

Donmez

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

“…Using a converted boiler as a hyperbaric chamber in Kansas City, Missouri (altitude 909 ft), Cunningham replicated this improvement caused by altitude descent on human disease when he treated an agonal Spanish flu patient in 1918, achieving complete recovery with four daily 1-h 1.6 ATA hyperbaric air treatment (HBAT) sessions ( 6 , 7 ) Countless Spanish flu patients followed, and Cunningham extended his clinical treatment benefits to a variety of conditions ( 7 – 9 ). After a hundred years, his reasoning and success were replicated in the application of hyperbaric oxygen therapy (HBOT) to COVID-19 ( 10 – 12 ) . and post-COVID “Long Haulers Syndrome.” ( 13 – 15 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Dementia sensitivity to altitude changes and effective treatment with hyperbaric air and glutathione precursors

Fogarty,

Harch

2024

Front. Neurol.

View full text Add to dashboard Cite

A 78-year-old man with dementia experienced waxing and waning of symptoms with changes in altitude as he traveled from his home in the Rocky Mountains to lower elevations and back. To replicate the improvement in his symptoms with travel to lower elevations (higher pressure), the patient was treated with a near-identical repressurization in a hyperbaric chamber using compressed air. With four 1-h treatments at 1.3 Atmospheres Absolute (ATA) and concurrent administration of low-dose oral glutathione amino acid precursors, he recovered speech and showed improvement in activities of daily living. Regional broadcast media had documented his novel recovery. Nosocomial COVID-19 and withdrawal of hyperbaric air therapy led to patient demise 7 months after initiation of treatment. It is theorized that hyperbaric air therapy stimulated mitochondrial biochemical and physical changes, which led to clinical improvement.

show abstract

“…Four RCTs with a total of 227 patients are published, with different pressure protocols ranging from 1.45-2.5 atmosphere absolute (ATA) for 60-90 minutes over a total of 5-10 sessions. Common outcomes in these small and heterogeneous studies have been "faster correction of hypoxemia" and "attenuation of inflammatory markers" (6)(7)(8)(9)(10). Importantly, HBOT is used as an adjuvant treatment for various infections and known to modulate the immune system by downregulating inflammatory cytokines such as TNF and IL-6 (11).…”

Section: Introductionmentioning

confidence: 99%

Fast recovery of COVID-19-induced acute respiratory distress syndrome after hyperbaric oxygen treatment and changes in endoplasmic reticulum (ER) stress response in peripheral monocytes – A randomized-controlled trial

Kjellberg,

Zhao,

Lussier

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Many questions remain unanswered regarding the scientific understanding of SARS-CoV-2 and host interaction. There is an established need to develop anti-inflammatory agents with the potential to prevent or mitigate the development of severe COVID-19, targeting viral replication and/or the immune response. To address these unmet needs, we investigated the effects of oxygen treatment (HBOT) on clinical inflammatory markers, peripheral blood cells and transcriptional changes in patients with severe COVID-19. Methods: In this pre-defined sub-study of a randomized controlled clinical trial, critical COVID-19 patients with moderate acute respiratory distress syndrome (ARDS) at one Swedish university hospital were enrolled and randomly assigned (1:1) to HBOT plus best practice or best practice (Control) and followed up on nine visits for 30 days. HBOT was administered with five treatments at 2.4 atmospheres absolute (ATA) for 80 min each, the first seven days. Clinical inflammatory markers, lymphocyte phenotyping with flow cytometry, and bulk RNA sequencing (RNAseq) were analyzed on peripheral blood monocytes (PBMCs). Results: Between December 3rd 2020, and May 17th 2021, 23 patients were randomized, and 17 were analyzed. RNAseq revealed 791 differentially expressed genes in the HBOT group compared to 46 in the control group at Day 7 vs. baseline. Gene set enrichment analysis revealed unique decreases of the unfolded protein response (UPR) and inflammatory response in the HBOT group. The HBOT group recovered faster. National early warning score (NEWS) was lower in the HBOT group (ANOVA, F(8, 120) = 3.817, p < 0.001) and PaO2/FiO2 was higher in the HBOT group (Mixed effects model, F(8, 94) = 2.900, p < 0.01). The HBOT group had a shorter mean hospital length of stay (HLoS), 16 vs. 26 days (95.99% CI -16-0), p=0.045, saving ~300.000 USD. Conclusions: Pathways related to viral-induced ER stress with downregulation of the UPR and inflammatory response in critical COVID-19 patients treated with HBOT was significantly different compared to controls and associated with faster recovery and reduced HLoS. Trial registration: NCT04327505 (March 31, 2020) and EudraCT 2020-001349-37 (April 24, 2020)

show abstract

Clinical and biochemical short-term effects of hyperbaric oxygen therapy on SARS-Cov-2+ hospitalized patients with hypoxemic respiratory failure

Cited by 7 publications

References 40 publications

Microstructural alterations in hypoxia‐related BRAIN centers after COVID‐19 by using DTI: A preliminary study

Microstructural alterations in hypoxia‐related BRAIN centers after COVID‐19 by using DTI: A preliminary study

Case report: Dementia sensitivity to altitude changes and effective treatment with hyperbaric air and glutathione precursors

Fast recovery of COVID-19-induced acute respiratory distress syndrome after hyperbaric oxygen treatment and changes in endoplasmic reticulum (ER) stress response in peripheral monocytes – A randomized-controlled trial

Contact Info

Product

Resources

About