Clinical and Biological Concepts for Mastering Immune Reconstitution After Hematopoietic Cell Transplantation: Toward Practical Guidelines and Greater Harmonization
Jürgen Kuball,
Raffaella Greco,
Stefan Nierkens
et al.
Abstract:Not only the underlying mechanisms driving a long-term cure but also life-threatening side effects after hematopoietic cell transplantation (HCT) are primarily mediated by reconstitution of the immune repertoire. The composition and dynamics of reconstitution are influenced by the conditioning regimen, cell dose, graft composition, and age and type of immune suppression. However, our understanding of these mechanisms is limited due to many variations in clinical programs, including the specific type of transpl… Show more
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