Clinical and Blood Pictures in Adult Scurvy

Jennings, G. H.; Glazebrook, Allison

doi:10.1136/bmj.2.4058.784

Cited by 14 publications

(5 citation statements)

References 4 publications

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“…The bone marrow has most often been described as normoblastic (Mettier et al 1930; McMillan and Inglis 1944; Vilter et al 1946; Brown 1951), but it may be megaloblastic as in the present case (Jennings and Glazebrook 1938; McMillan and Inglis 1944; Vilter et al 1946; R. Vilter 1947; Brontë‐Stewart 1953; Brown 1955; Neilson 1960; Will and Murdoch 1960), hyperplastic (Mettier et al 1930; Brontë‐Stewart 1953) or hypoplastic (Harris 1928; Wolbach 1937; Israëls 1943). Witts (1932) considered that vitamin C deficiency led to a maturation defect in the bone marrow.…”

Section: Discussionmentioning

confidence: 69%

“…Several workers have since shown that vitamin C deficiency without clinical scurvy is not associated with an increased incidence of anaemia (Croft and Snorf 1939; Lui, Chu, Yu, Hsu and Cheng 1941; Lozner 1941; Schulze and Morgan 1946; Vilter et al 1946). Nevertheless, cases of scurvy with anaemia which respond to the administration of vitamin C alone, with no other haemopoietic factor, continue to be described (Parsons and Hawksley 1933; Parsons and Smallwood 1935; Dunlop and Scarborough 1935; McFarlane 1936; Nisenson and Cohen 1937; Jennings and Glazebrook 1938; Parsons 1938; Young 1938; Kenney and Rapoport 1939; Braganca and Saha 1943; Vilter et al 1946; C. Vilter 1947; R. Vilter 1947; Brown 1951; Brontë‐Stewart 1953; Brown 1955; Neilson 1960; Will and Murdoch 1960; Cox et al 1962 and the present authors).…”

Section: Discussionmentioning

confidence: 99%

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Scurvy, Megaloblastic Anaemia and Osteoporosis

Hyams

Ross

1963

Int J Clinical Practice

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Clinical scurvy in the adult is uncommon in this country so that the opportunities for observing its complications are infrequent. One of these, megaloblastic anaemia, is well recognized, but osteoporosis of a degree sufficient to produce crush fractures of vertebrae is rare. This paper records observations on a patient with scurvy complicated by megaloblastic anaemia and osteoporosis who was treated with vitamin C as the sole medication. Case HistoryMrs. D. K., a housewife aged 54, was admitted to University College Hospital (St. Pancras Hospital) on 30th June, 1959. She had been well until a year before admission. Low back pain then developed and later she experienced cramps in the calves and difficulty in walking. Her ankles then became swollen. Extensive ecchymoses appeared on the lower limbs two weeks before admission. The patient thought that she had lost. 3. 4 inches in height in the past year, during which she had attended another hospital for low back pain. She had been provided with a plaster cast, and later a spinal brace, but these appliances had made her back stiffer and she had refused further treatment. She had also consulted an osteopath.The day before admission to hospital she had developed very se\'ere lumbar pain, • like a knife in my back'; her husband volunteered the information that the pain had been so severe that she had threatened to put her head in a gas oven.The patient was menopausal, menstruation having ceased at the age of 50. In her past history she had diphtheria at the age of 18, but nothing else of note apart from the exanthemata of childhood.The patient's husband's place of work was 40 miles away from home. He left at a very early hour in the morning and returned home late at night. The patient felt lonely and neglected and did not trouble to prepare cooked meals for herself. A dietary history showed that the patient's diet had been very deficient of vitamin C for about 3 years, although her intake of calcium and vitamin D had been reasonable (Table I). She had lived almost entirely on sandwiches. Vege• * Now senior medical registrar, _.,,_ddenbrookl''s Hospital, Cambridge TABLE I Calculate,d daily die1ary inlake ot patient Calories 1540 Carbohydrate (g.) 212 Fat (g.) 59 Protein (g.) 40 Calcium (mg.) 566 Iron (mg.) 8. Vilamin C (mg.) 3 Vitamin D (1.U.) 151The fundamental treatment for hay fever, asthma and other allergies is

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Scurvy, Megaloblastic Anaemia and Osteoporosis

Hyams

Ross

1963

Int J Clinical Practice

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“…The marrow findings were also similar to those recorded by others. These earlier findings were: (a) a gelatinous mass with failure of erythropoiesis (1 case) (Harris, 1927-8); (b) moderate hyperplasia with scattered small groups of erythroblasts and no fibrosis (1 case) (Mettier et al, 1930); (c) one normal marrow, and one megaloblastic marrow associated with macrocytosis and achylia gastrica (Jennings and Glazebrook, 1938); and (d) one normal marrow and two showing diminished erythropoiesis (Israels, 1943). The change from a megaloblastic to a normoblastic type with only dietary replacements was interesting.…”

Section: Treatmentmentioning

confidence: 94%

Scurvy: A Survey of 53 Cases

McMillan¹,

Inglis²

1944

BMJ

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“…In occasional cases there has been a rapid increase in the degree of anaemia despite increased reticulocytosis (Mettier et al, 1930;Jennings and Glazebrook, 1938;Vilter et al, 1946;Bronte Stewart, 1950;Brown, 1951).…”

Section: Commentmentioning

confidence: 99%